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Flashcards in ANS Deck (45):
1

Function of somatic nervous system?

-activate skeletal muscle contration
-sensory/afferent go to CNS
-motor/efferent go from CNS to skeletal muscle
-VOLUNTARY

2

autonomic nervous system function?

-smooth muscle, cardiac, metabolic activities
-INVOLUNTARY

3

primary NT in the sympathetic NS?
parasympathetic NS?

-Norepi
-ACH

4

where is ACH released?

-all autonomic ganglia (sym and parasym)
-parasym neuroeffector junction
-somatic neuromuscular junction

5

Epi is released from where?

adrenal medulla in response to activation of sympathetic

6

Dopamine is released where?

peripheral sympathetic fibers

7

parasym effects

-rest and digest
-specific response
-increase GI function
-increase urination
-decrease HR
-bronchoconstriction

8

sym effects

-fight or flight
-diffuse response
-increased heart rate
-bronchodilation
-decreased GI function
-decreased urination

9

pupil adrenergic receptor

A1

10

heart rate adrenergic receptor

B1

11

smooth muscle adrenergic receptor

B2

12

gastric secretion adrenergic receptor

B

13

pancreas secretion adrenergic receptor

A

14

arteries/veins adrenergic receptor and liver adrenergic receptor

A1/B2

15

salivary secretion adrenergic receptor

A1, B

16

effects of stimulating muscarinic receptors (ACH)

Salivation
Lacrimation
Urination
Defacaion
GI motility
Erection
also decrease HR, bronchoconstriction

17

effects of stimulating nicotinic receptors (ACH)

opposite effects of muscarinic
tachycardia, HTN

18

A1 adrenergic receptors function

-constrict blood vessels
-constrict vascular smooth muscle

19

A2 adrenergic receptors function

-inhibition of NE release from nerve endings at pre-synaptic post ganglionic neuron

20

B1 adrenergic receptor function

-cardiac stimulation (increase HR)
-increased lipolysis

21

B2 adrenergic receptor function

-smooth muscle relaxation
-glycogenolysis in liver/muscle

22

direct agonists work by activating

postsynaptic receptors

23

indirect agonists work by

-stimulating release in NT
-inhibit reuptake of NT
-inhibit metabolism of NT

24

direct antagonists work by

blocking postynaptic receptors

25

indirect antagonists work by

-inhibiting synthesis of NT
-prevent vesicular storage of NT
-inhibit release of NT

26

ACH and carbachol activate...

-nicotinic and muscarinic (direct cholinergic agonist)
-for COAG, miosis

27

bethanechol activates....

-only muscarinic (direct cholinergic agonist)
-stimulates bladder w/o effect on HR/BP

28

this is used to treat dry mouth associated with Sjogren's disease

cevimeline (exovac)

29

common muscarinic receptor antagonists

-atropine
-scopalamine
these inhibit effect of PNS stimulation (increase HR, smooth muscle relaxation)

30

ocular, respiratory and cardiac effects of muscarinic receptor antagonists

ocular-mydriasis, dry eye
respiratory-increase bronchodilation
cardiac-increase HR,, used for bradycardia

31

drug to treat parkinsons

benztropine (muscarinic antagonist)

32

direct acting adrenergic agonists

-epi/NE/dopamine
-albuterol/phenylephrine

33

indirect adrenergic agonists

-amphetamine
-cocaine

34

Alpha 1 adrenergic agonist produces....
Beta 1
Beta 2

-vasoconstriction, increased BP
-cardiac stimulation
-vasodilation, bronchiole relaxation

35

catecholamines are metabolized via

MAO and COMT

36

epi can bind to all adrenergic receptors to produce....

-vasoconstriction and increase BP
-cardiac stimulation
-bronchodilation

37

function of isoproterenol

used to treat asthma (B2 bronchodilation), AV block, bradycardia (B1 cardiac stim)

38

function of dopamine

used to treat cardiogenic shock, septic shock, heart failure

39

function of dobutamine

-used to treat cardiogenic shock, cardiac arrest, heart failure
-highest affinity for B1 receptor

40

direct adrenergic agonist (non-catecholamines)
-phenylephrine
-albuterol
-clonidine
-terbutaline

-vasoconstriction, increase BP. (A1)..used as nasal decongestant
-bronchodilation (B2)
-treat chronic HTN, inhibits NE release (feedback inhibition A2)
-asthma and premature labor, bronchodilation and uterine relaxation (B2)

41

indirect adrenergic agonists
amphetamine
cocaine
tyramine

-increase release of NE and dopamine from SNS, causes vasoconstriction, increase HR and BP
-stimulates SNS by blocking reuptake of NE and dopamine in the PNS and SNS
-normal by product of tyrosine metabolism, indirect sympathomimetic b/c it causes release of stored catecholamines, avoid if taking MAOI

42

nonselective A blockers block....and include these drugs

-a1 and a2 receptors
-phenoxybenzamine (treats hypertensive episodes associated w/pheochromocytome)
-phentolamine

43

selective A1 blockers end in....and their function

"azosin"
-relax smooth muscle, bladder, and prostate
-produces vasodilation and decreased BP
-treats HTN, urinary retention from BPH

44

Non selective B blockers function

"olol"
B1-decrease BP, CO, renin release
B2-bronchoconstriction
-used to treat HTN, angina, MI

45

selective B blockers function

-selective for B1 (cardiac)
-produce less bronchoconstriction
-atenolol/metoprolol
-used to treat HTN