Flashcards in Basics Deck (27):
biochemical and physiological effect of drugs and MOA
study of how the body absorbs, distributes, metabolizes and excretes drugs
Clinical testing of drugs phase 1
-clinical pharmacology (small group 20-80)
-clinical investigation (larger group 100-300)
-clinical trial (largest group 1k-3k)
-post marketing studies
1 ounce = how many ccs/ml?
1 mL = how many ccs?
1 tsp = how many ccs?
1 tbsp =how many ccs?
we prefer drugs with a ( ) TI
3 types of drug actions
-drug that combines w/receptor and activates
-stimulates release of an endogenous chemical
-drug that combines w/receptor used by an endogenous chemical and blocks/diminishes the response
a partial agonist has ( ) affinity but ( ) efficacy
if the dose of drug A is less than drug B to achieve same response, A is more potent
magnitude of the maximum biologic effect
tolerance vs dependence
tolerance-reduced response to same/increased dose due to change in receptor sensitivity
dependence-pt needs a drug to function normally
most drugs pass through membranes via
first pass effect
drugs that are well absorbed in the GI tract and are metabolized by the liver have decreased bioavailability
Drugs that are bound to anything other than a receptor are ( )
the brain is highly ( )
Phase I metabolism and main enzyme
non-synthetic oxidation, reduction, hydrolysis
Phase II metabolism
predominant CYP450 isoform
CYP3A4 (benzos, HIV, Ca blockers)
most studied genetic polymorphism
CYP2D6 (psychotropics, codeine, beta blockers)
the control of excreting a drug is via the
kidneys and is pH related
rate at which the drug is eliminated from the body
how many half lives for non-therapeutic?
out of body?
combined effect is greater than the sum
inactive drug increases effect of another
one drug increases the drug-metabolizing enzyme activity of another