ANS and CNS Pharmacotherapy Flashcards Preview

Nervous System > ANS and CNS Pharmacotherapy > Flashcards

Flashcards in ANS and CNS Pharmacotherapy Deck (30)
Loading flashcards...
1

PNS Effect on Heart

  • M2: decrease HR, conductance, and AV

2

PNS Effect on Vessels

  • PNS had no effect.
  • [M] present, but not innervated; vasodilation by muscarinic agonist only.

3

PNS Effect on Lungs

  •  [M] Bronchial Constriction

4

PNS Effect on Eye

  • [M] Miosis (constriction) and Focus
  • [M} Increase in aqueous humor outflow

5

PNS Effect on GI

  • [M] Increase motility (paralytic Ileus) and secretion (Xerostomia)

6

PNS Effect on GU

  • [M] open sphincter and contract bladder/detrusor muscle

7

PNS Effect on NMJ

[Nm} Muscle Contraction

8

PNS Effect on CNS

M: Memory, Cognition, and Movement

9

SNS Effect on Heart

  • [B1] Increase HR, conduction, and AV

10

SNS Effect on Vessels

  • [a1] constriction (increase BP in resistance vessels)
  • [B2] dilate and increase BF, and therefore perfusion to skeletal muscles
  • [a2] decrease in blood pressure

11

SNS Effect on Lungs

  • [B2] bronchioles dilate, increase in humor production (increase in IOP), promote uterine relaxation

12

SNS Effect on Eye

  • [a1] mydriasis (dilatiaon of pupil)
  • [B2] Increase aqueous humor, which increases intraocularpressure.

13

SNS Effect on GI

  • [B2,3] decrease contraction in detrusor muscle
  • B1- increased renin in kidney

14

SNS Effect on GU

  • [a2] decrease ACh release

15

Cholinergic (PNS) Agonists

  • [M] Pilocarpine, Bethanecol
  • (i) Neostigmine, Pyridosigmine, Edrophonium, Donepezil, Organophosphate Nerve Gas

16

Cholinergic (PNS) Antagonists

  • [M] Atropine, Scopolamine, Benztropine, Oxybuytnin, Tolterodine, Ipratropium, Tiotropium
  • [Nm] Atracurium, Rocuronium, Succinylcholine

17

Adrenergic (SNS) Agonists

  • [a1, B1, B2] epinephrine
  • [a1, B1] NE
  • [B1, B2] Isoproterenol
  • [B2] Albuterol
  • [a1] Phenylephrine
  • [i] Pseudoephrine (increase storage and release)
  • [B1] Dobutamine
  • [i] Dopamine [D1]

18

Adrenergic (SNS) Antagonists

  • [a1] Prazosin, Doxazosin, Terazosin
  • [B1] Metoprolol, Atenolol
  • [B1, B2] Propanolol
  • {a1. B1, B2] Labetalol, Carvedilol
  • [a2 agonist] Clonidine

19

Seizure Pathophysiology

  • Decrease GABA, Increase Glu

20

Anxiety Pathophysiology

  • Decrease GABA, increase NE, decrease 5'HT

21

Insomnia Pathophysiology

  • decrease in GABA

22

Alzheimer's Pathophysiology

  • increase Glu, decrease ACh

23

Pain

  • increase Glu, increase NE, increase 5'HT

24

Anesthesia

  • increase GABA, decrease Glu

25

Parkinson's Pathophysiology

  • Increase ACh, decrease DA

26

Psychoses Pathophysiology

  • decrease ACh (nicotinic), increase DA

27

Depression Pathophysiology

  • decrease in serotonin and NE

28

CNS Effects with:

  • Muscarinic Agonist
  • Muscarinic Antagonist
  • Adrenergic Agonist
  • Adrenergic Antagonist

  • Muscarinic Agonist: memory, cognition, movement [Alzheimer's]
  • Muscarinic Antagonist: [Parkinson's, Anti-Emetic]
  • Adrenergic Agonist: Increase vigilence and focus [ADHD]
  • Adrenergic Antagonist: [Stage Fright, Essential Tremor]

29

NMJ Effects with:

  • Muscarinic Agonist
  • Muscarinic Antagonist
  • Adrenergic Agonist
  • Adrenergic Antagonist

  • Muscarinic Agonist: Muscle Contraction [Myasthenia Grvais]
  • Muscarinic Antagonist: Flaccid Paralysis [Surgery- Muscle Relaxation]
  • Adrenergic Agonist: [B2] Muscle tremors
  • Adrenergic Antagonist: N/A

30