ANS and CNS Pharmacotherapy Flashcards Preview

Question 1

1

PNS Effect on Heart

Answer

M2: decrease HR, conductance, and AV

Question 2

2

PNS Effect on Vessels

Answer

PNS had no effect.
[M] present, but not innervated; vasodilation by muscarinic agonist only.

Question 3

3

PNS Effect on Lungs

Answer

[M] Bronchial Constriction

Question 4

4

PNS Effect on Eye

Answer

[M] Miosis (constriction) and Focus
[M} Increase in aqueous humor outflow

Question 5

5

PNS Effect on GI

Answer

[M] Increase motility (paralytic Ileus) and secretion (Xerostomia)

Question 6

6

PNS Effect on GU

Answer

[M] open sphincter and contract bladder/detrusor muscle

Question 7

7

PNS Effect on NMJ

Answer

[Nm} Muscle Contraction

Question 8

8

PNS Effect on CNS

Answer

M: Memory, Cognition, and Movement

Question 9

9

SNS Effect on Heart

Answer

[B1] Increase HR, conduction, and AV

Question 10

10

SNS Effect on Vessels

Answer

[a1] constriction (increase BP in resistance vessels)
[B2] dilate and increase BF, and therefore perfusion to skeletal muscles
[a2] decrease in blood pressure

Question 11

11

SNS Effect on Lungs

Answer

[B2] bronchioles dilate, increase in humor production (increase in IOP), promote uterine relaxation

Question 12

12

SNS Effect on Eye

Answer

[a1] mydriasis (dilatiaon of pupil)
[B2] Increase aqueous humor, which increases intraocularpressure.

Question 13

13

SNS Effect on GI

Answer

[B2,3] decrease contraction in detrusor muscle
B1- increased renin in kidney

Question 14

14

SNS Effect on GU

Answer

[a2] decrease ACh release

Question 15

15

Cholinergic (PNS) Agonists

Answer

[M] Pilocarpine, Bethanecol
(i) Neostigmine, Pyridosigmine, Edrophonium, Donepezil, Organophosphate Nerve Gas

Question 16

16

Cholinergic (PNS) Antagonists

Answer

[M] Atropine, Scopolamine, Benztropine, Oxybuytnin, Tolterodine, Ipratropium, Tiotropium
[Nm] Atracurium, Rocuronium, Succinylcholine

Question 17

17

Adrenergic (SNS) Agonists

Answer

[a1, B1, B2] epinephrine
[a1, B1] NE
[B1, B2] Isoproterenol
[B2] Albuterol
[a1] Phenylephrine
[i] Pseudoephrine (increase storage and release)
[B1] Dobutamine
[i] Dopamine [D1]

Question 18

18

Adrenergic (SNS) Antagonists

Answer

[a1] Prazosin, Doxazosin, Terazosin
[B1] Metoprolol, Atenolol
[B1, B2] Propanolol
{a1. B1, B2] Labetalol, Carvedilol
[a2 agonist] Clonidine

Question 19

19

Seizure Pathophysiology

Answer

Decrease GABA, Increase Glu

Question 20

20

Anxiety Pathophysiology

Answer

Decrease GABA, increase NE, decrease 5'HT

Question 21

21

Insomnia Pathophysiology

Answer

decrease in GABA

Question 22

22

Alzheimer's Pathophysiology

Answer

increase Glu, decrease ACh

Question 23

23

Pain

Answer

increase Glu, increase NE, increase 5'HT

Question 24

24

Anesthesia

Answer

increase GABA, decrease Glu

Question 25

25

Parkinson's Pathophysiology

Answer

Increase ACh, decrease DA

Question 26

26

Psychoses Pathophysiology

Answer

decrease ACh (nicotinic), increase DA

Question 27

27

Depression Pathophysiology

Answer

decrease in serotonin and NE

Question 28

28

CNS Effects with:

Muscarinic Agonist

Muscarinic Antagonist

Adrenergic Agonist

Adrenergic Antagonist

Answer

Muscarinic Agonist: memory, cognition, movement [Alzheimer's]
Muscarinic Antagonist: [Parkinson's, Anti-Emetic]
Adrenergic Agonist: Increase vigilence and focus [ADHD]
Adrenergic Antagonist: [Stage Fright, Essential Tremor]

Question 29

29

NMJ Effects with:

Muscarinic Agonist

Muscarinic Antagonist

Adrenergic Agonist

Adrenergic Antagonist

Answer

Muscarinic Agonist: Muscle Contraction [Myasthenia Grvais]
Muscarinic Antagonist: Flaccid Paralysis [Surgery- Muscle Relaxation]
Adrenergic Agonist: [B2] Muscle tremors
Adrenergic Antagonist: N/A

Question 30

30

Brainscape's Knowledge GenomeTM

ANS and CNS Pharmacotherapy Flashcards Preview

Nervous System > ANS and CNS Pharmacotherapy > Flashcards

PNS Effect on Heart

M2: decrease HR, conductance, and AV

PNS Effect on Vessels

PNS had no effect. [M] present, but not innervated; vasodilation by muscarinic agonist only.

PNS Effect on Lungs

[M] Bronchial Constriction

PNS Effect on Eye

[M] Miosis (constriction) and Focus [M} Increase in aqueous humor outflow

PNS Effect on GI

[M] Increase motility (paralytic Ileus) and secretion (Xerostomia)

PNS Effect on GU

[M] open sphincter and contract bladder/detrusor muscle

PNS Effect on NMJ

[Nm} Muscle Contraction

PNS Effect on CNS

M: Memory, Cognition, and Movement

SNS Effect on Heart

[B1] Increase HR, conduction, and AV

SNS Effect on Vessels

[a1] constriction (increase BP in resistance vessels) [B2] dilate and increase BF, and therefore perfusion to skeletal muscles [a2] decrease in blood pressure

SNS Effect on Lungs

[B2] bronchioles dilate, increase in humor production (increase in IOP), promote uterine relaxation

SNS Effect on Eye

[a1] mydriasis (dilatiaon of pupil) [B2] Increase aqueous humor, which increases intraocularpressure.

SNS Effect on GI

[B2,3] decrease contraction in detrusor muscle B1- increased renin in kidney

SNS Effect on GU

[a2] decrease ACh release

Cholinergic (PNS) Agonists

[M] Pilocarpine, Bethanecol (i) Neostigmine, Pyridosigmine, Edrophonium, Donepezil, Organophosphate Nerve Gas

Cholinergic (PNS) Antagonists

[M] Atropine, Scopolamine, Benztropine, Oxybuytnin, Tolterodine, Ipratropium, Tiotropium [Nm] Atracurium, Rocuronium, Succinylcholine

Adrenergic (SNS) Agonists

[a1, B1, B2] epinephrine [a1, B1] NE [B1, B2] Isoproterenol [B2] Albuterol [a1] Phenylephrine [i] Pseudoephrine (increase storage and release) [B1] Dobutamine [i] Dopamine [D1]

Adrenergic (SNS) Antagonists

[a1] Prazosin, Doxazosin, Terazosin [B1] Metoprolol, Atenolol [B1, B2] Propanolol {a1. B1, B2] Labetalol, Carvedilol [a2 agonist] Clonidine

Seizure Pathophysiology

Decrease GABA, Increase Glu

Anxiety Pathophysiology

Decrease GABA, increase NE, decrease 5'HT

Insomnia Pathophysiology

decrease in GABA

Alzheimer's Pathophysiology

increase Glu, decrease ACh

Pain

increase Glu, increase NE, increase 5'HT

Anesthesia

increase GABA, decrease Glu

Parkinson's Pathophysiology

Increase ACh, decrease DA

Psychoses Pathophysiology

decrease ACh (nicotinic), increase DA

Depression Pathophysiology

decrease in serotonin and NE

CNS Effects with: Muscarinic Agonist Muscarinic Antagonist Adrenergic Agonist Adrenergic Antagonist

Muscarinic Agonist: memory, cognition, movement [Alzheimer's] Muscarinic Antagonist: [Parkinson's, Anti-Emetic] Adrenergic Agonist: Increase vigilence and focus [ADHD] Adrenergic Antagonist: [Stage Fright, Essential Tremor]

NMJ Effects with: Muscarinic Agonist Muscarinic Antagonist Adrenergic Agonist Adrenergic Antagonist

Muscarinic Agonist: Muscle Contraction [Myasthenia Grvais] Muscarinic Antagonist: Flaccid Paralysis [Surgery- Muscle Relaxation] Adrenergic Agonist: [B2] Muscle tremors Adrenergic Antagonist: N/A

Key Links

Subjects

Company

Find Us

Brainscape's Knowledge Genome^TM

PNS had no effect.

[M] present, but not innervated; vasodilation by muscarinic agonist only.

[M] Miosis (constriction) and Focus

[M} Increase in aqueous humor outflow

[a1] constriction (increase BP in resistance vessels)

[B2] dilate and increase BF, and therefore perfusion to skeletal muscles

[a2] decrease in blood pressure

[a1] mydriasis (dilatiaon of pupil)

[B2] Increase aqueous humor, which increases intraocularpressure.

[B2,3] decrease contraction in detrusor muscle

B1- increased renin in kidney

[M] Pilocarpine, Bethanecol

(i) Neostigmine, Pyridosigmine, Edrophonium, Donepezil, Organophosphate Nerve Gas

[M] Atropine, Scopolamine, Benztropine, Oxybuytnin, Tolterodine, Ipratropium, Tiotropium

[Nm] Atracurium, Rocuronium, Succinylcholine

[a1, B1, B2] epinephrine

[a1, B1] NE

[B1, B2] Isoproterenol

[B2] Albuterol

[a1] Phenylephrine

[i] Pseudoephrine (increase storage and release)

[B1] Dobutamine

[i] Dopamine [D1]

[a1] Prazosin, Doxazosin, Terazosin

[B1] Metoprolol, Atenolol

[B1, B2] Propanolol

{a1. B1, B2] Labetalol, Carvedilol

[a2 agonist] Clonidine

CNS Effects with:

Muscarinic Agonist

Muscarinic Antagonist

Adrenergic Agonist

Adrenergic Antagonist

Muscarinic Agonist: memory, cognition, movement [Alzheimer's]

Muscarinic Antagonist: [Parkinson's, Anti-Emetic]

Adrenergic Agonist: Increase vigilence and focus [ADHD]

Adrenergic Antagonist: [Stage Fright, Essential Tremor]

NMJ Effects with:

Muscarinic Agonist

Muscarinic Antagonist

Adrenergic Agonist

Adrenergic Antagonist

Muscarinic Agonist: Muscle Contraction [Myasthenia Grvais]

Muscarinic Antagonist: Flaccid Paralysis [Surgery- Muscle Relaxation]

Adrenergic Agonist: [B2] Muscle tremors

Adrenergic Antagonist: N/A