Drug Targets in Neurologic Disorders Flashcards by M Ho

Q

Pathophysiology of Alzheimers

A

Decrease in ACh-M Pathway; Increase in Glu excitotoxicity.

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Q

Pathophysiology of Acute Chronic Pain

A

Abnormal PG, ion channels, 5HT, Glu; increase sensitization in pain pathways

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Q

Pathophysiology of Parkinson’s Disease

A

decrease in striatal DA release, which increase ACh and increase GABA inhibition.

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Q

Pathophysiology of Seizure Disorders

A

Complex: abnormal VSSC-VSCC, decrease in GABA, and increase in Glu neuronal activity.
Tx: increasing GABA activity, block VSSC and VSCC

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Q

A

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