Drug Targets in Neurologic Disorders Flashcards Preview

Nervous System > Drug Targets in Neurologic Disorders > Flashcards

Flashcards in Drug Targets in Neurologic Disorders Deck (5)
Loading flashcards...
1

Pathophysiology of Alzheimers

  • Decrease in ACh-M Pathway; Increase in Glu excitotoxicity.

2

Pathophysiology of Acute Chronic Pain

  • Abnormal PG, ion channels, 5HT, Glu; increase sensitization in pain pathways

3

Pathophysiology of Parkinson's Disease

  • decrease in striatal DA release, which increase ACh and increase GABA inhibition.

4

Pathophysiology of Seizure Disorders

  • Complex: abnormal VSSC-VSCC, decrease in GABA, and increase in Glu neuronal activity.
  • Tx: increasing GABA activity, block VSSC and VSCC

5