Antagonists Flashcards
Naloxone: Class
Nonselective Opioid Antagonist
Naloxone: Use
Reverse Opioid induced respiratory depression
Naloxone: Mechanism of Action
Pure opioid antagonist that competes and displaces opioids at opioid receptor sites
Naloxone: Dose
40 mcg Boluses
Naloxone: Pharmacokinetics
Absorption: IV, Intranasal, SQ
Onset: 1 minute
Duration of Action: 30 minutes
Metabolism: Liver
Excretion: Kidneys
Naloxone: Contraindications
Hypersensitivity
Acute Opioid withdrawal
Naloxone: Considerations
Medications 1/2 is shorter than the 1/2 of opioids
Can Cause:
Pulmonary Edema, Tachycardia, HTN
Flumazenil: Class
Competitive Benzodiazepine Antagonist
Flumazenil: Use
To reverse the respiratory depressive effects of benzodiazepines
Flumazenil: Mechanism of Action
It competitively inhibits the benzodiazepine binding site on the GABA/benzodiazepine receptor complex
Flumazenil: Dose
Initial IV: 0.2mg
Titrate by 0.1mg increments
Flumazenil: Pharmacokinetics
Absorption: IV
Onset: 1 minute
Duration of Action: 30 minutes
Metabolism: Hepatic
Excretion: Kidneys
Flumazenil: Contraindictions
Avoid with Seizure patients on Anti-epileptics
Flumazenil: Considerations
Chronic Benzo use may lead to acute withdrawal
Short 1/2 life
can lead to a rebound effect
