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Anti anemia drugs Flashcards

(70 cards)

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1
Q

Routes of Administration (ROA) of Carbonyl Iron and Ferrous Gluconate

A

oral preferred given usually over 3-6 months

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2
Q

ROA for ferric gluconate

A

IV

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3
Q

ROA for iron dextran

A

IV/IM given to people with documented Fe anemia or people who can’t tolerate pills

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4
Q

Elimination method of endogenous iron

A

none

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5
Q

what form is iron stored in ferritin

A

Fe+3 ferric

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6
Q

where is iron stored

A

bone marrow, liver, duodenum

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7
Q

How is iron transported and in what form is it transported in?

A

Transferrin transports iron in the ferric form to TfR in the bone marrow to bind with heme

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8
Q

Where is iron absorbed

A

duodenum, jejunun, ileum

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9
Q

Clinical Use (CU) of ferric gluconate

A

given to pts with chronic hemodialysis

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10
Q

CU of carbonyl iron, ferrous gluconate

A

given for iron def anemia over 3-6 months

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11
Q

CU of iron dextran

A

pts must have a documented case of anemia

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12
Q

Adverse effects of carbonyl iron and ferrous gluconate

A

dark stools

BBW overdose in little kids

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13
Q

Adverse effects of ferric gluconate

A

n/v/d, hypotension

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14
Q

Adverse effects for iron dextran

A

BBW analphylatic rxn

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15
Q

Tx for acute iron toxicity

A

bowel irrigation or iron antidote (deferoxamine )

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16
Q

chronic iron toxicity

A

iron overload hemochromatosis

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17
Q

most common form of hemochromatosis

A

HFE polymorphism

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18
Q

Iron dextran contraindications

A

Category C for pregnant women

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19
Q

ROA of Deferoxamine

A

oral, SC, IV

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20
Q

ROA for Deferasirox

A

oral

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21
Q

how is deferoxamine excreted

A

urine

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22
Q

how is deferasirox excreted

A

feces

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23
Q

Clinical uses of iron chelators

A

binds to the ferric form of iron and inactives it

does not bind to ferrous form on heme

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24
Q

Clinical use of Deferoxamine

A

acute iron toxicity and chronic iron overload

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25
Clinical Use of Deferasirox
chronic iron overloading from blood transfusions
26
Adverse effects of deferoxamine
growth retardation, neuropahy
27
contraindications of deferoxamine
renal failure, pregnancy rating category c
28
adverse effects for deferasirox
BBW---high creatitine levels, renal failure, GI bleed, liver failure
29
contraindications of deferasirox
EPASS enrollees
30
Cyanocobalamin two active forms in the body
methocobalamin and deoxyadenocobalamin
31
b12 is absorbed with what
intrinsic factor
32
ROA of b12
oral, IM, SC, nasal
33
Where is b12 stored ?
liver
34
how much b12 do we loose daily?
trace amounts found in urine and feces (would require 3-5 years to become b12 def if we stopped consummation to date)
35
THF is a
cofactor
36
Clinical uses of B12
treat and prevent b12 deficiencies
37
B12 defs present with
megaloblastic anemia with neurological problems
38
Can u treat a b12 def individual with folic acid?
yes, it will cure the mega anemia but not the neurological issues
39
Diagnostics for b12
serum vitamin levels | elevated homocysteine and l-methylmalonyl acid `
40
Schilling test uses what
radio labeled b12 that is excreted in the urine
41
Pernicious anemia
presents on a schilling test with low levels of b12 in urine without IF
42
Damage to distal ileum
presents on schilling test with lower levels of b12 in urine with IF and w/o
43
If a malabsorption issue is noted for a b12 def, pt needs treatment in what form
parental (IV)
44
selected adverse of effects of cyclocobalamin
CHF, analphyaxis, pain at injection site
45
contraindications of cyclocobalamine
leber's optic nerve
46
ROA for folic acid
topical, IV, oral, IM
47
Absorption of folic acid
distal ileum stored in the liver
48
pregnant woman requires
300-400 micrograms per day | adult 50-200 daily
49
CU of folic acid
tx of megaloblastic anemia due to a folic acid def
50
oral administration only
in pregnant women preventiing neural tube defects
51
topical ROA
anti-aging creams
52
IV administration only
methanol poisoning
53
adverse effects
sleeping issues, bronchiospasms, irritability
54
contraindications of folic acid
un diagnosable anemia
55
ROA of Leucovorin
oral, IV, IM
56
Leocovorin is a cofactor for
THF (methylene THF and methyl-THF)
57
Leu is absorbed
in the small intestine
58
Leuco enters into the folic acid cycle
as a cofactor for THF | bypasses the DHF phase where methotrexate is acting on
59
LEucovorin clinical use
rescues cells exposed to folate antagonists-methotrexate
60
oral adim of leucovorin only in
trimethoprim toxicity
61
IV admin of leucovorin
methanol poisoning and advanced colorectal cancers
62
5-FU is used for colorectal cancers explain its reaction with leucovorin
leucovorin binds to THF THF then binds to 5-FU activates TS to increase cytotoxic effects
63
Darbepoetin alpha Epoetin alpha
recombinant human pro tine of EPO
64
ROA of Epoetin
IV/SC 3 times a week
65
Darbepoetin alpha
IV/SC once weekly
66
Pharmacodynamics of Darb and Epoetin
binds to EPO receptors on PM of progenitor cells in bone marrow
67
Administration of Darb and Epo alpha
respond to the tissue hypoxia
68
Clinical uses of Darbopoetin alpha
anemia associated with chronic kidney disease | chemotherapy related anemia
69
What do patients usually receive with Darbopeotin alpha
iron and folate tx
70
Clinical uses of Epoetin alpha
anemia assoc with chronic kidney disease chemotherapy related anemia zidovodine related anemia PRE OP blood transfusions

MINI 4 (23 decks)

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