Anti-hyperlipidaemics - Cholesterol absorption inhibitor

Question 1

In addition to fibrates and statins, there are cholesterol absorption inhibitors that are able to inhibits NPC1L1 transporters in GIT, thus reducing lipid absorption. What is the core drug under this class of drug?

1 - Simvastatin
2 - Atorvastatin
3 - Bezafibrate
4 - Ezetimibe

Answer 1

4 - Ezetimibe

Question 2

In addition to fibrates and statins, there are cholesterol absorption inhibitors. What is the mechanism of action of this group of drugs?

1 - inhibit HMG-CoA) reductase
2 - inhibit pancreatic lipase
3 - inhibits Niemann-Pick C1-like 1 protein (NPC1L1) transported in GIT
4 - inhibit lipoprotein lipase

Answer 2

3 - inhibits Niemann-Pick C1-like 1 protein (NPC1L1) transported in GIT

• reduced lipid absorption

Question 3

Which of the following does Ezetimibe, the cholesterol absorption inhibitors affect the most?

1 - HDL
2 - VLDL
3 - LDL
4 - chylomicrons

Answer 3

3 - LDL

Question 4

Ezetimibe, the cholesterol absorption inhibitor we need to be aware of is indicated in all of the following EXCEPT which one typically?

1 - adjunct to dieting + statin for primary hypercholesterolaemia
2 - adjunct to dieting + statin in homozygous familial hypercholesterolaemia,
3 - idiopathic hypertension with contraindications for statins
4 - Primary hypercholesterolaemia (if statin inappropriate or not tolerated),
5 - adjunct to dieting in homozygous sitosterolaemia

Answer 4

3 - idiopathic hypertension with contraindications for statins

Question 5

Which of the following are common adverse events of Ezetimibe, the cholesterol absorption inhibitor?

1 - GI upset and disorders
2 - rashes
3 -liver damage
4 - all of the above

Answer 5

4 - all of the above

Question 6

Is Ezetimibe, the cholesterol absorption inhibitor recommended in pregnant or breast feeding women?

Answer 6

• no
• found in breast milk