Anti Infectives in Dentistry

Question 1

How many generations does penicillin have?

Answer 1

3

Question 2

Subgroup of First Gen Pencillin

Answer 2

1. Pen G
2. Pen V
3. Penicillinase Resistance penicillin

Question 3

3 groups of Pen G

Answer 3

*Sodium & Potassium Pen G
*Procaine Pen G *Benzathine Pen G

Question 4

Very potent bactericidal agent acts by interfering w synthesis of bacterial cell wall

Answer 4

Penicillin

Question 5

ROA of Penicillin

Answer 5

Administered orally, parentally but not topically

Question 6

ADVERSE REACTION: PENICILLIN

Answer 6

1 Hypersensitivity reactions
3 Oxacillin
2 Oral penicillin
4 Extended spectrum pen

Question 7

Symptoms of hypersensitivity reac

Answer 7

1.1 Rashes
1.3 Drug Fever
1.2 Anaphylactic reaction
1.4 Serum reaction (occurs wk/two)

Question 8

major adverse reaction to penicillin

Answer 8

1 HYPERSENTIVITY REACTIONS (RADS)

Question 9

ORAL PENICILLIN (DNT) symptoms

Answer 9

2.1 Diarrhea
2.2 Nausea & Vomiting 2.3 Tongue inflammation

Question 10

causes liver toxicity

Answer 10

3 OXACILLIN (TO)

Question 11

diarrhea causes by: CO
* Change in flora of the colon or
* Overgrowth of toxin producing strain of Clostridium difficile

Answer 11

Pseudo membranous colitis

Question 12

exclusively in dental situations when oral narrow spectrum antibiotic is indicated

Answer 12

Pen V

Question 13

Pseudo membranous colitis is diarrhea caused by (1) (2)

Answer 13

• Change in flora of the colon or
• Overgrowth of toxin producing strain of Clostridium difficile

Question 14

Pen V Examples

Answer 14

Metronidazole
Tetracycline not often used
Penicillin
Clindamycin soft tissue infection
Erythromycin
Minocycline periodontist

Question 15

“prototype penicillin”

Answer 15

PENICILLIN G

Question 16

Pen G is poorly absorbed _____ used _____ on a daily bases

Answer 16

(1) orally
(2) large doses

Question 17

Choose: Benzathine pen G, Sodium Potassium Pen G, Procaine Pen G

P: detrimental to px w cv disease on low sodium diet

Answer 17

SODIUM & POTASSIUM PEN G

Question 18

Choose: Benzathine pen G, Sodium Potassium Pen G, Procaine Pen G

U: Combination with oral PROBENECID single dose injection for treatment of certain sexually transmitted disease

Answer 18

PROCAINE PEN G

Question 19

Choose: Benzathine pen G, Sodium Potassium Pen G, Procaine Pen G

ROA: IM (Intramuscular) provide extended duration of action

Answer 19

BENZATHINE PEN G

Question 20

Procaine is used in combination w _______

Answer 20

oral PROBENECID

Question 21

1 Cloxacillin & 2 Dicloxacillin is an example of ______

Answer 21

PRP

Question 22

3 EXTENDED SPECTRUM PENICILLIN:

Answer 22

1 Ampicillin
like agents
2 Carbenicillin
like agents
3 Amidino penicillin

Question 23

Ampicillin or Carbenicillin like Agents

Parenteral ampicillin
+ Gentamycin
for high risk cardiac px

Answer 23

Ampicillin

Question 24

Ampicillin or Carbenicillin like Agents

Combined w Gentamycin or Tobramycin

Answer 24

Carbenicllin

Question 25

Ampicillin or Carbenicillin like Agents

Indication orally for treatment of
urinary tract infection

Answer 25

Carbenicillin

Question 26

Ampicillin or Carbenicillin like Agents

Purpose / For: HESS

Answer 26

Ampicillin

H. Influenzas, E.Coli, Salmonella, Shigella

Question 27

Dental Antibiotic (5)

Answer 27

Clindamycin
Erythromycin Cephalosporins
Metronidazole Tetracyclines

Question 28

Dental Antibiotic: effective against anaerobic microorganism Bacteroides & some staphylococcal infections

Answer 28

Clindamycin

Question 29

medical use: to inhibit amoebiasis,
trichomoniasis

effectiveness in treating dry sockets

improvement in periodontal px

Answer 29

METRONIDAZOLE

Question 30

good alternative to penicillin, not really used in dentistry

Answer 30

ERYTHROMYCIN

Question 31

ERYTHROMYCIN drug of choice (7) (GLADCWS)

Answer 31

Gonorrhea
Legionnaire’s disease
Atypical pneumonia
Diptheria
Chlamydia infection
Whooping cough
Syphillis

Question 32

Whooping cough

Answer 32

ERYTHROMYCIN

Question 33

Reduce rate of elimination of Theophylline (high dose)
chronic asthma

Answer 33

ERYTHROMYCIN

Question 34

ERYTHROMYCIN

Adult Dose:

Child Prophylaxis

Bacterial Prophylaxis

Answer 34

(1) 250 - 500 qid (4x a day)

(2) 10 - 20 mg/kg

(3) 1 mg (1 hr before dental appointment) followed by
500 mg in 6 hrs

Question 35

interferes w synthesis of bacterial protein by binding at 30s subunit of bacterial ribosome

Answer 35

TETRACYCLINE

Question 36

Tetracycline: If used during enamel calcification (1) (1)

Answer 36

can produce PE
1 permanent discoloration of the teeth
2 enamel hypoplasia

Question 37

Age for primary teeth to be affected

Answer 37

4 - 6 mos

Question 38

Age for permanent teeth to be affected

Answer 38

2 months - 8 yrs

Question 39

All Tetracyclines enter the cerebrospinal fluid but insufficient to be therapeutic except for ______

Answer 39

Minocycline

Question 40

Dairy food in diet: dec absorption T. except w ______

Answer 40

Doxycycline

Question 41

All Tetracyclines: metabolized in the

Answer 41

liver

Question 42

Tetracycline Use for treatment of

Answer 42

Chlamydial infections
Ricketts
Mycoplasma Pneumonia
Cholera
Localized Juvenile Periodontitis (LJP)

Acne: effectively treated in low dosage, can dec fatty acid content of sebum

Question 43

____ : excreted in urine; _____ : excreted in feces

Answer 43

Minocycline; Doxycycline

Question 44

Tetracycline: eliminated by ____

Answer 44

glomerular filtration

Question 45

AR of photosensitivity reactions, red rash on areas exposed to sunlight

Answer 45

TETRACYCLINE

Question 46

chemically related to penicillin; inhibits Salmonella, Klebsiella

Answer 46

CEPHALOSPHORINS

Question 47

Prophylaxis before dental procedure:
to prevent bacterial endocarditis but not a substitute to penicillin or erythromycin

Answer 47

CEPHALOSPHORINS