Anti-Microbials Flashcards Preview

Pharmacology > Anti-Microbials > Flashcards

Flashcards in Anti-Microbials Deck (15):
0

Sulphonamides

Inhibit DHOp synthase
PABA to DHOp

1

Trimethoprim

Inhibits DHF reductase
DHF to THF
Additional target and hyperproduction

2

Quinolones

Ciprofloxacin
Inhibits DNA gyrate and topoisomerase 4
Alter target enzymes/drug permeation

3

Rifamycins

Rifampicin
Inhibits bacterial RNA polymerase

4

Macrolides

Erythromycin
Inhibits ribosomes

5

Glycopeptides

Vancomycin
Prevents PtG synthesis by binding to the pentapeptide

6

B lactams

Cephalosporins, Carbapenems and Penicillins
Bind covalently to transpeptidase, inhibiting PtG incorporation into cell wall

7

Glycolipids/lipopeptides

Daptomycin
Cell wall stability
Disrupt gram positive cell walls

8

Polymyxins

Bind to LPS and disrupts gram negative cell membranes

9

Flucloxacillin

Penicilliin
Inhibits transpeptidase
B lactamase resistant

10

Amoxacillin with clavulanic acid

Broad spectrum
Gram negative activity

11

Isoniazid

Anti mycobacterial
Tuberculosis treatment
With rifampicin
Mycolic acid synthesis inhibitor

12

Rifampicin

Anti mycobacterial
Tuberculosis tretatment 6 month
With isoniazid
RNA polymerase inhibitor
Also for leprosy

13

Fluconazole

Azoles
Anti fungal
Inhibit cp450 enzymes and ergo sterol synthesis for cell wall
Candidiasis and systemic infections

14

Amphotericin

Polyenes
Antifungals
Interact with cell membrane sterols forming membrane channels
Systemic infections