Antiarrhythmic Drugs

Question 1

Cardiac Na+ Channels

Answer 1

1a – Quinidine จับกลางๆ AP duration Prolong

1b – Lidocaine phase 0 ล็อกได้น้อยสุด

1c – Flecainide จับปล่อยช้าสุด

Question 2

Class II β-blocker

Answer 2

Nonselective β blockers: Propranolol

Selective β1-adrenergic receptor blockers: Metoprolol,

Question 3

Class III K+ channel Amiodarone, Dronedarone, Ibutilide, Dofetilide, modulators

Answer 3

Amiodarone

Question 4

Class IV Ca2+ channel blockers

Answer 4

Verapamil, Diltiazem

Question 5

Verapamil, Diltiazem

Answer 5

Adenosine agonists – Adenosine

Muscarinic blockers – Atropine

Question 6

Subgroup 1A: Quinidine Pharmacokinetics?

Answer 6

potent inhibitors of CYP3A4

• Procainamide: hepatic metabolism to an active metabolite NAPA

Question 7

Subgroup IB