Antibacterials

Question 0

What is the MOA of vancomycin?

Answer 0

Block peptidoglycan synthesis

Question 1

What is the MOA of beta-lactam antibiotics?

Answer 1

Block cell wall synthesis by inhibition of peptidoglycan cross-linking

Question 2

What is the MOA of sulfonamide/trimethoprim (SMX/TMP)?

Answer 2

Block nucleotide synthesis by inhibiting folic acid synthesis (pteridine synthetase/dihyrdofolate reductase)

Question 3

What is the MOA of quinolones?

Answer 3

Block DNA gyrase (topoisomerase II) and topoisomerase IV

Question 4

What are the AE of penicillin?

Answer 4

GI disturbances

Hematologic toxicity

Elevated liver function test

Renal toxicity

Allergic reactions

Electrolyte disturbance

CNS toxicity

Question 5

What penicillin is clinically indicated for syphilis?

Answer 5

Penicillin G

Question 6

What penicillin is a repository formulation for IM administration?

Answer 6

Penicillin G Benzathine

Question 7

What penicillin is stable in gastric acid and ideal for oral dosing?

Answer 7

Penicillin V

Question 8

What penicillin is primarily used for parenteral treatment of serios staphylococcal infections and Streptococcus pneumoniae?

Answer 8

Oxacillin

Question 9

What penicillin is used for oral treatment of staphylococcal infections including osteomyelitis?

Answer 9

Dicloxacillin

Question 10

What penicillin covers pseudomonal infections?

Answer 10

Piperacillin

Ticarcillin

Question 11

What organisms are typically not covered by cephalosporins?

Answer 11

LAME

Listeria

Atypical (Chlamydia and Mycoplasma)

MRS

Enterococci

Ceftaroline covers MRSA

Question 12

True or false, the higher the generation of cephalosporins then the more superior the activity against gram negative organisms?

Answer 12

True

Question 13

Imipenem is always administerd with what drug?

Answer 13

Cilastatin

Question 14

What is the MOA of rifampin?

Answer 14

Block mRNA synthesis

Question 15

What is the MOA of macrolides?

Answer 15

Block protein synthesis at 50S ribosomal subunit

Question 16

What is the MOA of chlorampenicol?

Answer 16

Block protein synthesis at 50S ribosomal subunit

Question 17

What is the MOA of clindamycin?

Answer 17

Block protein synthesis at 50S ribosomal subunit

Question 18

What is the MOA of linezolid?

Answer 18

Block protein synthesis at 50S ribosomal subunit

Question 19

What is the MOA of aminoglycosides?

Answer 19

Block protein synthesis at 30S ribosomal subunit

Question 20

What is the MOA of tetracyclines?

Answer 20

Block protein synthesis at 30S ribosomal subunit

Question 21

What are the AE of vancomycin?

Answer 21

Nephrotoxicity

Ototoxicity

Thrombophlebitis

Red man syndrome

Question 22

What are the AE of aminoglycosides?

Answer 22

Nephrotoxicity

Ototoxicity

Neuromuscular blockade

Teratogenic

Question 23

What tetracycline is clinically indicated for leptospirosis?

Answer 23

Doxycycline

Question 24

Which macrolide has a long half life?

Answer 24

Azithromycin

Question 25

What macrolide is used to treat Helicobater pylori infections in conjuection with bismuth subcitrate or proton pump inhibitor?

Answer 25

Clarithromycin

Question 26

What are the AE of macrolide?

Answer 26

Motility issues Arrhythmia caused by prolonged QT Acute cholestatic hepatitis Rash Eosinophilia

Question 27

What non-beta-lactam antibiotic are not usually taken with milk, antacids or iron-containing preparations?

Answer 27

Tetracycline Quinolone

Question 28

What are the AE of chloramphenicol?

Answer 28

Anemia Aplastic anemia Gray baby syndrome

Question 29

What are the AE of trimethoprim?

Answer 29

Megaloblastic anemia Leukopenia Granulocytopenia

Question 30

What happens when you take metronidazole and alcohol at the same time?

Answer 30

Disulfiram-like reaction

Question 31

What is the first line drug for uncomplicated typhoid fever?

Answer 31

Chloramphenicol

Question 32

What are the AE of clindamycin?

Answer 32

Pseudomembranous colitis Fever Diarrhea

Question 33

What aminoglycoside is a first line drug against tuberculosis?

Answer 33

Streptomycin

Question 34

What antibiotic may cause discoloration of teeth and hypoplasia of the enamel?

Answer 34

Tetracycline

Question 35

What is the first line drug for Burkholderia cepacia and Stenotrophomonas maltophilia?

Answer 35

Co-trimoxazole

Question 36

What drug is clinically indicated for antibiotic associsted psudomembranous colitis?

Answer 36

Vancomycin (PO)

Question 37

What drug is clinically indicated for MRSA?

Answer 37

Vancomycin (IV)

Question 38

What is first quinolone to be produced?

Answer 38

Nalidixic acid

Question 39

What is the drug of choice for Shigella infections?

Answer 39

Ciprofloxacin

Question 40

What is the primary measure of antibiotic activity?

Answer 40

Minimum inhibitory concentration (MIC)

Question 41

G6PD deficiency is contraindicated for what antibiotics?

Answer 41

Sulfonamides Chloramphenicol Isoniazid Nitrofurantoin

Question 42

What is the most common cause of UTI in all ages?

Answer 42

Escherichia coli

Question 43

What is the most common cause of pneumonia in ages 3 months to 5 years old?

Answer 43

Haemophilus influenzae Streptococcus pneumoniae Staphylococcus aureus

Question 44

What is the most common cause of early onset neonatal sepsis?

Answer 44

Escherichia coli