Systems Pharmacology Flashcards

Question

What is the MOA of mebendazole?

Answer 1

Inhibits microtubule synthesis

Answer 2

Reduces hepatic and renal gluconeogenesis

Answer 3

Blocks vascular L-type Ca cahnnels

Answer 4

Prototype first-generation proton pump inhibitor; Irreversiblity inhibits H/K-ATPase pump in stomach parietal cells

Answer 5

5-HT3 antagonist in gut and CNS

Answer 6

β-lactam that binds to penicillin binding protein which inhibits cell wall synthesis

Answer 7

Prototype barbiturate; Binds and enhances phasic GABA-A receptor at CNS neuronal synapsesincreasing duration of GABA-mediated Cl channel opening thereby enhancing membrane hyperpolarization

Answer 8

Prototype selective α1 adrenoreceptor antagonist

Answer 9

Alters gene expression; may trigger apoptosis

Answer 10

Prototype nonselective β adrenoreceptor antagonist (β1 and β2)

Answer 11

New-generation H2 antagonist; Reversibly blocks histamine H2 receptors

Answer 12

Short-acting selective β2 adrenoreceptor agonist

Answer 13

K-sparing diuretic; Blocks aldosterone receptor in renal collecting tubule and androgen receptor (weak)

Answer 14

Selective β2 adrenoreceptor agonist

Answer 15

Serious ventricular arrhythmia Supraventricular arrhythmia (Class III anti-arrhythmic)

Answer 16

Antipyretic Analgesic Anti-inflammatory Antiplatelet

Answer 17

``` Retinal examination (mydiasis and cycloplegia) Prevent synechiae after surgery Antidote for severe cholinesterase inhibitor poisoning ```

Answer 18

Hypertension Heart failure Diabetes

Answer 19

``` Gram-positive cocci Haemophilus influenzae Enterobacter Neisseria spp. Proteus mirabilis Escherichia coli Klebsiella pneumoniae Serratia marcescens ```

Answer 20

``` Typhoid fever (Salmonella typhi) Meningitis or epiglottitis (Haemophilus influenzae) ```

Answer 21

Peptic ulcer GERD Erosive gastritis

Answer 22

Gram-negative rod of urinary and GI infections

Answer 23

Hypertension

Answer 24

UTI Acute otitis media Traveler's diarrhea Pneumocystis carinii prophylaxis in immunocompromised hosts

Answer 25

Muscle relaxation Intractable seizure disorders Anxiety disorders Insomnia and other sleep disorders

Answer 26

Allergies Sedative Antiemetic Antimotion sickness

Answer 27

Acute decompensated heart failure | Cardiogenic shock

Answer 28

Chronic symptomatic heart failure | Rapid ventricular rate in atrial fibrillation

Answer 29

Hypertension Heart failure Diabetes

Answer 30

Anaphylaxis Asthma (rare) Open-angle glaucoma Hypotension

Answer 31

Peptic ulcer GERD Erosive gastritis

Answer 32

Severe hypertension (especially emergencies) Heart failue Edematous conditions (pulmonary, peripheral) Hypercalcemia Hyperkalemia Acute renal failure Anion overdose

Answer 33

Type 2 diabetes

Answer 34

``` Hypertension Mild heart failure Hypercalciuria Nephrolithiasis Nephrogenic diabetic insipidus ```

Answer 35

``` Addison's disease Inflammation Immune suppression Asthma Anaphylaxis ```

Answer 36

Type 1 and 2 diabetes

Answer 37

``` Asaris Trichuris Hookworm Pinworm Capillaria ```

Answer 38

Type 2 diabetes

Answer 39

Hypertension | Angina

Answer 40

Peptic ulcer GERD Erosive gastritis

Answer 41

First-line agents in cancer chemotherapy emesis | Useful also in postop emesis

Answer 42

Staphylococcus aureus

Answer 43

Seizure disorders

Answer 44

Hypertension | Benign prostatic hyperplasia

Answer 45

``` Cancer chemotherapy Chronic lymphocytic leukemia Non-Hodgkin's lymphoma Immunosuppresant Asthma controller ```

Answer 46

``` Hypertension Angina Atrial arrhythmia Migraine Hyperthyroidism Prevention of recurrent infarction and sudden death ```

Answer 47

Peptic ulcer GERD Erosive gastritis

Answer 48

Asthma and COPD reliever

Answer 49

``` Aldosteronism (cirrhosis and adrenal tumor) Heart failure Nephrotic syndrome Hypertension Hypokalemia due to diuretics Postmyocardial infarction ```

Answer 50

Prolong gestation in premature labor cases

Answer 51

``` Bradycardia Heart block in diseased heart Peripheral vasodilation Pulmonary and hepatic toxicity Hyper or hypothyroidism ```

Answer 52

Gastric ulcer Tinnitus Reye's syndrome in children Acute renal failure, interstitial nephritis and upper GI bleeding (chronic use) Respiratory alkalosis and metabolic acidosis (overdose)

Answer 53

``` Increased intraoccular pressure in closed-angle glaucoma Muscle weakness (overdose) ```

Answer 54

``` Cough Angiodema Hyperkalemia Renal impairment Tertogenicity ```

Answer 55

Hypersensitivity reactions | Vitamin K deficiency

Answer 56

Gray baby syndrome Dose-related anemia Idiosyncratic aplastic anemia

Answer 57

``` Potent inhibitor of cytochrom P450 Decrease renal excretion of creatinine Diarrhea Dizziness Rashes Headache Confusion Somnolence Decreased libido Impotence Gynecomastia Blood dyscrasia, hepatotoxicity and nephrotoxicity (rare) ```

Answer 58

``` GI upset Skin rashes Neurotoxicity Tendonitis Pregnancy contraindicated Cartilage damage in children Prolonged QT interval ```

Answer 59

Dry mouth Sedation Orthostatic hypotension REbound hypertension

Answer 60

``` Hypersensitivity reactions Hemolysis (G6PD deficient) Nephrotoxicity Photosensitivity Kernicterus in infants Megaloblastic anemia Leukopenia Granulocytopenia ```

Answer 61

Extension of CNS depressant effects Dependence liability Sedation

Answer 62

Sedation Muscarinic blockade symptoms Orthostatic hypotension

Answer 63

Nausea Vomitting Diarrhea Arrhythmia

Answer 64

``` Cough Angiodema Hyperkalemia Renal impairment Tertogenicity ```

Answer 65

``` Tremor Tachycardia Nausea Vomitting Headache Dizziness ```

Answer 66

Increased risk of Clostridium difficile infection | Hip fractures

Answer 67

``` Hypovolemia Hypokalemia Hypomagnesia Hyperuricemia Orthostatic hypotension Ototoxicity Sulfonamide allergy ```

Answer 68

Hypoglycemia | Weight gain

Answer 69

``` Hyponatremia Hypokalemia Hyperglycemia Hyperlipidemia Hyperuricemia Hypercalcemia Sulfonamide allergy Metabolic alkalosis ```

Answer 70

``` Iatrogenic Cushing's syndrome Adrenal insufficiency (abrupt stop after chronic use) ```

Answer 71

Hypoglycemia Weight gain Lipodystrophy (rare)

Answer 72

Less sedation than first-generation H1 antgonist

Answer 73

``` Nausea Vomitting Diarrhea Abdominal pain Hypersensitivity reactions Agranulocytosis Alopecia Elevation of liver enzymes ```

Answer 74

GI symptoms Lactic acidosis (rare) Weight loss

Answer 75

Excessive hypotension | Baroreceptor reflex tachycardia

Answer 76

Increased risk of Clostridium difficile infection | Hip fractures

Answer 77

Headache | Constipation

Answer 78

Hypersensitivity reactions | Interstitial nephritis

Answer 79

``` Extension of CNS depressant effects Greater dependence liability Sedation Cognitive issues Ataxia Hyperactivity ```

Answer 80

Orthostatic hypertensions (first dose)

Answer 81

``` Cushing-like symptoms Immunosuppresion Cataracts Acne Osteoporosis Hypertension Peptic ulcer Hyperglycemia Psychosis ```

Answer 82

``` Bradycardia Worsened asthma Fatigue Vivid dreams Cold hands AV block Acute heart failure Sedation ```

Answer 83

``` Decrease renal excretion of creatinine Diarrhea Dizziness (less than cimetidine) Rashes Headache (less than cimetidine) Confusion (less than cimetidine) Somnolence (less than cimetidine) Decreased libido (less than cimetidine) Impotence (less than cimetidine) Gynecomastia (less than cimetidine) Blood dyscrasia, hepatotoxicity and nephrotoxicity (rare) ```

Answer 84

Tremor | Tachycardia

Answer 85

``` Hyperkalemia Antiandrogen effect (gynecomastia) ```

Answer 86

``` Hypotension β1 stimulated reflex tachycardia Arrhytmia Pulmonary edema Bradycardia with abrupt withdrawal Nausea Headcahe Muscle tremor ```

Systems Pharmacology Flashcards

(114 cards)