Autacoids

Question 1

True or false, H4 receptors are found in bone marrow and white blood cells?

Answer 1

True

Question 2

Which is not a function of 5-HT: regulation of GI motility and presitalsis, bronchodilation, chemical transmitter for tryptaminergic neurons of the brain and precursor of melatonin?

Answer 2

Bronchodilation

Question 3

Which is not an H1 antagonist: chlorphenamine, fexofenadine, cimetidine and loratidine?

Answer 3

Cimetidine

Ranitidine

Question 4

True or false, cisapride is a 5-HT4 agonist for anxiety and depression?

Answer 4

False

Cisapride is for GI motility and presitalsis. Buspirone is for anxiety and depression.

Question 5

True or false, tissue damage cannot activate kallikrein-kininogen-kinin system?

Answer 5

False

Question 6

What vasoactive compound is the most potent vasoconstrictor?

Answer 6

Angiotensin II

Question 7

What drug is considered as a renin inhibitor?

Answer 7

Aliskerin

Question 8

What drug is a non-selective 5-HT receptor antagonist?

Answer 8

Ergotamin

Question 9

Gastrointestinal bleeding from aspirin is considered a?

Answer 9

Side effect

Question 10

Prostaglandin synthesis is blocked through what pathway?

Answer 10

Cyclooxygenase pathway

Question 11

The potency of ACE inhibitors like captopril can be explained by a dual action of?

Answer 11

Inhibition of synthesis of a powerful vasoconstrictor

Inhibition of destruction of a powerful vasodilator

Question 12

Angiotensin effects are reversed by?

Answer 12

Renin inhibitors

Angiotensin converting enzyme inhibitors

kininase II inhibitors

angiotensin receptor antagonist

Question 13

What drug is a selective serotonin widely used anxiolitic?

Answer 13

Buspirone

Question 14

5-HT in brain serotogenic neurons are involved in?

Answer 14

Mood, depression, anxiety

Sleep, apetite, vomitting

Pain, temperature regulation, migraine

Question 15

Serotonin is found in?

Answer 15

Enterochromaffin cells

Platelets which are able to concentrate the amine by means of active SERT

Nerve endings particularly brain serotogenic neurons as transmitter

Question 16

What is an example of a traditional antihistamines with sedative effects?

Answer 16

Diphenhydramine

Question 17

Histamine has the following?

Answer 17

Powerful effects on smooth and cardiac muscles

Endothelial cells and nerves

More effect on guinea pigs than humans

Gastric acid secretion

Question 18

What drug is an example of a lipoxygenase inhibitor?

Answer 18

Zileuton

Question 19

What drugs are an example of leukotriene-receptor antagonist?

Answer 19

Montelukast

Zafirlukast

Question 20

What drug is an example of a selective COX-2 inhibitor?

Answer 20

Celecoxib

Question 21

What drug is an analog of PGE₂ and used to reduce NSAID induced ulcers?

Answer 21

Misoprostol

Question 22

What anti-inflammatory drug binds uniquely to its receptor irreversibly?

Answer 22

Aspirin

Question 23

What enzymes are inhibited by NSAIDs like aspirin and ibuprofen?

Answer 23

COX-1

COX-2

Question 24

What are the clinical significance of prostanoids?

Answer 24

Platelet function

Inflammatory reaction

Reproduction

Question 25

What enzyme classes are responsible for converting tryptophan to serotonin?

Answer 25

Hydroxylase Decarboxylase

Question 26

What body functions involve 5-HT?

Answer 26

Fertility Feeding Mentation

Question 27

What are the therapeutic uses of H1 blockers?

Answer 27

Aid for sleeping Countering motion sickness Relieve itching and rashes in allergies

Question 28

Which of the following drugs is least sedating: loratadine, chlorpenamine, diphenhydramine and clemastine?

Answer 28

Loratadine

Question 29

What autacoids are involved in inflammation?

Answer 29

Histamine Bradykinin Serotonin Prostanoids