Antibiotics

Question 1

Which drugs are aminoglycosides?

Answer 1

T: Tobramycin
A: Amikacin
G: Gentamycin

Question 2

How do aminoglycosides work?

Answer 2

Inhibit protein synthesis in bacteria by binding to the 30S ribosomal subunit

Question 3

Toxic effects of aminoglycosides

Answer 3

nephrotoxic, ototoxic

Question 4

Clinical application of aminoglycosides

Answer 4

Treat gram negative bacterial infections that are resistant to less toxic antibiotics

Question 5

Vancomycin

Answer 5

Treatment of gram positive bacterial infections unresponsive to other antibiotics, interferes with ability of bacteria to form cell walls

Question 6

Toxic effects of vancomycin

Answer 6

Nephrotoxicity, Ototoxicity, Red man syndrome

Question 7

Chloramphenicol

Answer 7

Treatment of bacterial meningitis, concentrates in CSF. Inhibits protein synthesis in bacteria by binding the 50S ribosomal subunit, bacterialstatic

Question 8

Toxic effects of Chloramphenicol

Answer 8

Cardiovascular collapse (newborns), blood dyscrasias, anemia (maturation arrest)