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Flashcards in Antibiotics Deck (24):
1

ABx associated w/ ototoxicity

Aminoglycosides (ex gentamicin) >> Vacomycin
**causes PERMANENT senosorineural hearing loss

Minocycline cause transient vestibular dysfunction

2

ABx w/ nephrotxocity

-amphotericin B
**Aminoglycosides = ATN (classically = gentamicin)
-Vanco (especially when given w/ other nephrotox agents)

3

ABx w/ disulfiram like reactions

metronidazole

4

Red man syndrome

Vanco

5

Red lobster syndrome

Rifampin (red urine)

6

Disoclored teeth

Tetracyclines (not for kids <8y/o)

7

Yellow babies

sulfonamides (not for women near term or neonates)

8

Abx associated w/ c. diff

-Oral aminopenicillins (ex amoxicillin and ampicillin)
-Oral cephalosporins (ex cephalexin)
-Oral fluoroquinolones (ex levofloxacin)
**highest incidence = clindamycin

9

ABx and EBV

diffuse maculopapular, non-uriticarial rash
-any amino penicillin product can cause this (classically = ampicillin)

10

ABx that are B in pregnancy

-most beta-lactams (penicillins, cephalosporins, monobactams, carbapenems)
-clindamycin
-erythromycin/azithromycin
-metronidazole **except 1st trimester**
-oral vanco

11

ABx that are C in pregnancy

-clarithryomycin
-fluoroquinolones
-TMP/SMX
-IV vanco

12

Abx that are D in pregnancy

-aminoglycosides (gentamicin etc)
-tetracyclines

13

Aminoglycosides in pregnancy

possibly CN 8 toxicity in fetus

14

Tetracyclines in pregancy

tooth/bone problems for infant

15

Sulfonamides in pregnancy

newbown kernicterus

16

Fluoroquinolones in pregnancy

arthropathy

17

Macrolide warning/SE

-QTc prolongation issues (azithromycin = safety warning)
-Potent inhibitor of CYP3A4

18

Fluoroquinolones warning/SE

-don't mix w/ QTc prolonging drugs
-multivalent cations decrease absorption (aka milk products)
-not for kids <18
-CNS toxicity
-photosensitivity
-dysglycemia

19

TMP/SMX warning/SE

-moderatley inhibits CYP2C9---> watch Warfarin!!
-retains K ---> careful w/ ACEI/ARBs
-hypersensitivity rxns
-reversible myelosuppression
-hemolytic anemia in G6PD patients

20

Fluconazole warning

-inhibits CYP2C9 and CYP3A4 (watch warfarin and other drugs)

21

Gold standard for anti MSSA

dicloxacillin
(then cephalexin, doxy, TMP-SMX, clinda)

22

Anti MRSA abx

-linezolid and tedizolic
-doxy and minocycline
-TMP-SMX
-Clindamycin

23

Anti pseudomonal abx

-cipro and levo

24

Anti-anaerobic abx

Gold = metronidazole or amoxicillin/clavulanate
Silver = clindamycin