Antibiotics for CNS Infections Flashcards Preview

Hailey - Neuro > Antibiotics for CNS Infections > Flashcards

Flashcards in Antibiotics for CNS Infections Deck (29):
1

Antibacterials

Ceftriazone
Penicillin
Amocicillin, Ampicillin
Aztreonam
Vancomycin
Rifampin
Gentamicin, Amikacin

2

Antivirals

Acyclovir, Gancyclovir

3

Antifungals

Amphotericin B
Flucytosine 5-FC
Fluconazole

4

Antimycobacteria

Rifampin
Isoniazid
Pyrazinamide
Ethambutol

5

Ceftriaxone

3rd generation cephalosporin
CELL WALL INHIBITOR
binds to penicillin binding proteins
N. gonnorrhoeae conjunctivitis

6

Ceftriazone Tx options

EMPIRIC treatment of BACTERIAL MENINGITIS: Ceftriaxone and vancomycin
DEFINITIVE/PROPHYLACTIC treatment of Neisseria meningitis
EMPIRIC treatment of BRAIN ABSCESS: Ceftriazone and metronidazole

7

Penicillin

CELL WALL INHIBITOR
binds to penicillin binding proteins
high levels beta-lactam antibiotics in CNS block binding of GBA to receptors --> tissue becomes more excitable and prone to seizures
GRAM POSITIVE ONLY

8

Penicillin Tx

INTRAPARTUM PROPHYLAXIS for streptococcus agalactiae (STREP B)

9

Amoxicillin

CELL WALL INHIBITOR
binds to penicillin bidnging proteins
add clavulanate to inactivate enzymatic degradation by beta-lactamases

10

Amoxicillin Tx

Otitis media and sinusitis

11

Ampicillin

CELL WALL INHIBITOR
binds to penicillin binding proteins

12

Ampicillin Tx

Ampicillin + Gentamicin: Listeria monocytogenes meningitis

13

Aztreonam

CELL WALL INHIBITOR
binds to penicillin binding proteins

14

Aztreonam Tx

EMPIRIC treatment of MENINGITIS if beta-lactam allergy: Aztreonam + Vancomycin

15

Vancomycin

CELL WALL INHIBITOR
binds to the D-ala-D-ala shielding it from the transpeptidation reaction**
GRAM POSITIVE

16

Vancomycin Tx

MRSA
EMPIRIC treatment of meningitis with ceftriaxone

17

Rifampin

INHIBITS DNAd-RNApol
increases P-450 levels decreasing activity of other drugs

18

Rifampin Tx

PROPHYLAXIS Meningoccal for H. influenza type B and Mycobacterium tuberulcolosis

19

Gentamicin, Amikacin

PROTEIN SYNTHESIS INHIBITOR
binds 30S ribosomal subunit
oxotoxicity

20

Gentamicin, Amikacin Tx

Listeria monocytogenes meningitis: Gentamicin + Ampicillin

21

Acyclovir, Gancyclovir

INHIBITS VIRAL DNA POLYMERASE AND LEADS TO CHIAN TERMINATION
prodrugs must be phosphorylated by viral thymidine kinase leading to its selectivity
not effective against latent virus

22

Acyclovir, Gancyclovir Tx

HSV-1
HSV-2 (Acyclovir)
CMV (Gancyclovir)

23

Amphotericin B

DISRUPTS PLASMA MEMBRANES ALLOWING LEAKAGE OF ELECTROLYTES
lipsomal form enters CNS
nephrotoxic

24

Flucytosin (5-FU)

DNA SYNTHESIS INHIBIOR CONVERSION TO 5-fluorouracil

25

Flucytosin (5-FU) Tx

Flucytosin + amphotericin B: Cryptococcus, Candida inf

26

Fluconazole

DECREASES ERGOSTEROL SYNTHESIS

27

Fluconazole Tx

Candida

28

Isoniazid

MYCOLIC ACID INHIBITOR
difference in drug half-life depending on the pt is fast or slow acetylator

29

Ethambutol

CELL WALL INHIBITOR
binds arabinosyl transferase