Flashcards in Block 1 Extra Stuffz Deck (23):
CSF [glu] should be ___% of plasma [glu].
newborn defective glucose transporter Sx
at birth: staring, eye rolling, limb jerking, dazed
2.5mo: seizures, low CSF [glu], 3% head circ
low CSF [glu]
_____ affected by AD.
Hippocampus (memory) affected by AD.
MRI with contrast agent (gadolinium) detects _____.
Barrier permeability in hippocampus increases with ______.
aging and more severely in AD.
Major 3 adhesion proteins in tight junction of BBB
JAM (junctional adhesion molecule)
Two BBB membranes
luminal (blood side) and abluminal (brain side)
Drewes' favorite transporter
MCT1 monocarboxylate transporter 1 (transports lactate, pyruvate, acetate, butyrate, ketone bodies into brain)
no ionizing radiation
removes white CSF
12 transmembrane segments, ABC transporter
pumps DRUGS out of brain
Other BBB paths
transcytosis: by receptors (insulin) or absorptive (albumin)
diapedesis: immune cell migration (adhesion, emigration)
Trojan horse approach
carries things (drugs, antibodies) across the BBB membranes in unexpected ways
EG paclitaxel attaches to LRP-1, so carried across BBB unconventionally
When is BBB established?
Wnt signalling pathay, first few weeks
no tight junctions*
brain/CSF barrier = endothelial cells
Transporters in blood-CSF barrier (choroid plexus)
How they make CSF
carry ions to direction of CSF > makes area hyper osmotic > water flows in > makes CSF
inhibits Na/K ATPase