Block 1 Extra Stuffz Flashcards Preview

Hailey - Neuro > Block 1 Extra Stuffz > Flashcards

Flashcards in Block 1 Extra Stuffz Deck (23):
1

CSF [glu] should be ___% of plasma [glu].

67%

2

newborn defective glucose transporter Sx

at birth: staring, eye rolling, limb jerking, dazed
2.5mo: seizures, low CSF [glu], 3% head circ

3

hypoglycorrhachia

low CSF [glu]

4

_____ affected by AD.

Hippocampus (memory) affected by AD.

5

MRI with contrast agent (gadolinium) detects _____.

BBB permeability

6

Barrier permeability in hippocampus increases with ______.

aging and more severely in AD.

7

Major 3 adhesion proteins in tight junction of BBB

occludin
claudin
JAM (junctional adhesion molecule)

8

Two BBB membranes

luminal (blood side) and abluminal (brain side)

9

Drewes' favorite transporter

MCT1 monocarboxylate transporter 1 (transports lactate, pyruvate, acetate, butyrate, ketone bodies into brain)

10

CT for

INTRACRANIAL HEMORRHAGE
MASS EFFECT
quick

11

MRI for

ISCHEMIA
DEMYELINATING DISEASES
SEIZURES
TUMOR
longer
no ionizing radiation

12

Flair MRI

removes white CSF

13

p-glycoprotein

12 transmembrane segments, ABC transporter
efflux transporter
luminal membrane*
pumps DRUGS out of brain

14

Mdr1a/b

p-glycoproteins

15

Other BBB paths

transcytosis: by receptors (insulin) or absorptive (albumin)
diapedesis: immune cell migration (adhesion, emigration)

16

Trojan horse approach

carries things (drugs, antibodies) across the BBB membranes in unexpected ways

EG paclitaxel attaches to LRP-1, so carried across BBB unconventionally

17

When is BBB established?

Wnt signalling pathay, first few weeks

18

Choroid plexus

"fluffy" -Drewes
no tight junctions*
brain/CSF barrier = endothelial cells

19

Transporters in blood-CSF barrier (choroid plexus)

How they make CSF

Na/K/2Cl (NKCC)
Na/K ATPase

carry ions to direction of CSF > makes area hyper osmotic > water flows in > makes CSF

20

Furosemide

inhibits NKCC

21

Ouabain

inhibits Na/K ATPase

22

Acetazolamide

inhibits CA

23

glymphatic system

washes toxins out of brain