Antibiotics MOA

Question 1

D: Infection

Answer 1

Invasion & Multiplication of pathogenic microbes

Question 2

D: Antibiotic

Answer 2

Anti-bacterial medication (not including disinfectants)

Question 3

D: Antibacterial

Answer 3

Kills or inhibits growth of bacteria

Question 4

D: Bactericidal

Answer 4

Kills bacteria (affects bacterial cell wall)

Question 5

D: Bacteriostatic

Answer 5

Inhibits bacteria growth (affecting RNA/DNA)

Question 6

D: Broad spectrum Abx

Answer 6

Active against many bacteria (may kill normal flora)

Question 7

D: Narrow spectrum Abx

Answer 7

Active against a few bacteria (may not kill all pathogens)

Question 8

Minimum Bactericidal Concentration (MBC)

Answer 8

Lowest concentration that kills 99.9% of a population

Question 9

Minimum inhibitory concentration

Answer 9

Lowest concentration which inhibits visible growth of bacteria

Question 10

D: Breakpoint

Answer 10

MIC cut-of which separates strains where there is a high likelihood of tx succeeding from those where tx is more likely to fail

Question 11

What would you use against Tonsilitis?

Give name, class, MOA + any extras & SE

Answer 11

Penicillin

Class: Beta- Lactam- Penicillins

MOA: Bacteriocidal (inhibit synthesis of cell wall -> Cell lysis)

Question 12

What would you use against SSTI Straph. A initially?

Give name, class, any extras & SE

Answer 12

Flucloxacillin

Beta Lactam- Penicillin

MOA: Bacteriocidal- Penicillinase Resistant

Question 13

What would you use against SSTI strep

Give name, class, any extras & SE

Answer 13

Benzylpenicillin

Beta Lactam- Penicillin

MOA: Bacteriocidal

Question 14

What would you use against LRTI

Give name, class, any extras & SE

Answer 14

Amoxicillin

Beta- Lactam Penicillin

MOA: Bacteriocidal + Enhanced uptake by bacteria

Question 15

What would you use against Mixed infections?

Give name, class, any extras & SE

Answer 15

Co-Amoxiclav

Beta Lactam- Penicillin

MOA: Bacteriocidal + Beta Lactamase Inhibitor

Question 16

What are the Bacteriocidal Drug Classes?

Answer 16

Beta Lactams: Penicillins, Cephlosporins & Carbapenems

Question 17

When would you use Fluclox?

Answer 17

SSTI Staph A

Question 18

When would you use Benpen?

Answer 18

SSTI Strep

Question 19

When would you use Amoxicillin?

Answer 19

LRTI

Question 20

When would you use Co- Amoxiclav?

Answer 20

Mixed Chest infections

Question 21

When would you use Penicillin?

Answer 21

Tonsilitis

Question 22

What would you use against Infections in ITU/ Complex, Multidrug resistant UTIs

Give name, class, any extras & SE

Answer 22

Meropenem

Class: Beta Lactam Carbapenem

MOA: Bacteriocidal

Question 23

When would you use meropenem?

Answer 23

Infections in ITU

Complex, Multidrug resistant UTIs

Question 24

What would you use against: Bacterial meningitis, Abdominal Sepsis, Othro Infections?

Give name, class, any extras & SE

Answer 24

Cefatriaxone

Class: Beta Lactam- Cephlasporins

MOA: Bacteriocidal

SE: CDAD and 10% w/ penicillin allergy have alergy to this

Extra: Later generations increased acitivity spectrum but:

a) Kill more natural flora
b) Decreased activity against Gram +ve

Question 25

When do you use cefatriaxone?

Answer 25

Abdo sepsis, Ortho infections, Bacterial meningitis

Question 26

What are the Bacteriostatic drug clases?

Answer 26

Macrolides- Erythromyocin Lincosimides- Clindamyocin Tetracyclines- Tetra & Doxyclcyline

Question 27

What would you use against URTI, LRTI, SSTI, Atypical LRTI Give name, class, any extras & SE

Answer 27

Erythromyocin Class: Macrolide MOA: Bacteriostatic Notes: In place of penicillin. Atypical LRTI- eg: legionella

Question 28

What would you use Erythromyocin for?

Answer 28

LRTI, URTI, Atypical LRTI (eg: legionella), SSTI In place of penicillin

Question 29

What would you use against SSTI in place of penicillin Give name, class, any extras & SE

Answer 29

Clindomyocin Class: Lincosamide MOA: Bacteriostatic NOTES: In place of penicillin when IV access is limitied. Excellent bioavailability & tissue penetration when taken orally

Question 30

What would you use against an SSTI in place of penicillin?

Answer 30

Clindamyocin (Lincosimide)

Question 31

What would you use against Atypical Bacterial that lack a cell wall (eg: Chlamydia, Myoplasma Rickettsia infections eg: typhus) Give name, class, any extras & SE

Answer 31

Tetracycline/ Doxycycline Class: Tetracyclines MOA: Bacteriostatic SE: Photosensitivity, GI upset- Reflux, Oesophagitis, Diarrhoea

Question 32

When would you use Tetracyclines?

Answer 32

Atypical Bacteria that lack cell wall (eg: Chlamydia, Mycoplasma Rickettsia infections eg: typhus)

Question 33

What are the Bacterial DNA strucutre & Function Abx?

Answer 33

Nitromedazole Fluroquinolones- Cipro

Question 34

What would you use against: Anaerobic infections (absecess) Give name, class, any extras & SE

Answer 34

Metronidazole Class: Nitromidazole MOA: Bacterial DNA Strucutre & Function

Question 35

When would you use Metranidazole?

Answer 35

Anaerobic infections (abscess)

Question 36

What would you use against: Grame -ve infections, MRSA? Give name, class, any extras & SE

Answer 36

Ciprofloxacin Class: Fluroqionolones MOA: Bacterial DNA Structure & Function SE: CDAD

Question 37

When would you use Ciprofloxacin?

Answer 37

Gram -ve infections (excluding anaerobes) MRSA infections

Question 38

Which drugs induce CDAD?

Answer 38

Ciprofloxicin & Cefatriaxone

Question 39

What wold you use in place of Penicillin?

Answer 39

Macrolides- Erythromyocin Lincosamides- Clindamyocin