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Class: Microbiology > Antibiotics_Pilch > Flashcards

Flashcards in Antibiotics_Pilch Deck (9)
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1
Q

Aminoglycosides: Mechanism of Action

A

Bind to 30s ribosomal subunit and interfere with protein synthesis in 3 ways:

1) Blocking the initiation step
2) Blocking the ribosomal translocation step
3) Causing mistranslation (Bactericidal)

2
Q

Aminoglycosides: Effects

A

Bactericidal:

- Aerobic Gram Negative

3
Q

Which drug class has a Postantibiotic effect?

A

Aminoglycosides

4
Q

Streptomycin: Primary Clinical Indications

A

2nd line treatment for TB

- used in combination with INH and RIF

5
Q

Tobramycin and Gentamicin: Primary Clinical Indications

A

Tx of SERIOUS systemic infections
- Sepsis, Pneumonia

Often used in combination with B-Lactam drugs

6
Q

Amikacin: Primary Clinical Indications

A

Use in replacement of Tobramycin and Gentamicin

7
Q

Neomycin and Kanamycin: Primary Clinical Indication

A

Limited to topical use
- Skin and Eyes
- Other indications - injected into joints, pleural cavity, tissue spaces and abscess cavities
Too toxic to be used systemically

8
Q

Tetracyclines: Drug types

A
Tetracycline
Demeclocycline
Minocycline
Doxycycline
Tigecycline (Glycylcycline)
9
Q

Aminoglycosides (Drug)

A
Streptomycin
Tobramycin
Gentamicin
Amikacin
Neomycin
Kanamycin