Antibiotics_Pilch

Question 1

Aminoglycosides: Mechanism of Action

Answer 1

Bind to 30s ribosomal subunit and interfere with protein synthesis in 3 ways:

1) Blocking the initiation step
2) Blocking the ribosomal translocation step
3) Causing mistranslation (Bactericidal)

Question 2

Aminoglycosides: Effects

Answer 2

Bactericidal:

- Aerobic Gram Negative

Question 3

Which drug class has a Postantibiotic effect?

Answer 3

Aminoglycosides

Question 4

Streptomycin: Primary Clinical Indications

Answer 4

2nd line treatment for TB

- used in combination with INH and RIF

Question 5

Tobramycin and Gentamicin: Primary Clinical Indications

Answer 5

Tx of SERIOUS systemic infections
- Sepsis, Pneumonia

Often used in combination with B-Lactam drugs

Question 6

Amikacin: Primary Clinical Indications

Answer 6

Use in replacement of Tobramycin and Gentamicin

Question 7

Neomycin and Kanamycin: Primary Clinical Indication

Answer 7

Limited to topical use
- Skin and Eyes
- Other indications - injected into joints, pleural cavity, tissue spaces and abscess cavities
Too toxic to be used systemically

Question 8

Tetracyclines: Drug types

Answer 8

Tetracycline
Demeclocycline
Minocycline
Doxycycline
Tigecycline (Glycylcycline)

Question 9

Aminoglycosides (Drug)

Answer 9

Streptomycin
Tobramycin
Gentamicin
Amikacin
Neomycin
Kanamycin