Antibodies

Question 0

What antibodies are expressed on mature naïve B cells?

Answer 0

IgM and IgD.

Question 1

What antibodies are expressed on immature B cells?

Answer 1

IgM

Question 2

What antibodies are expressed on activated and memory B cells?

Answer 2

Any class. Depends on cytokine signals from TH cells.

Question 3

What is ADCC?

Answer 3

Antibody dependent cell-mediated cytotoxicity.

Question 4

What antibodies are involved in ADCC?

Answer 4

IgG and IgE

Question 5

What does ADCC enhance the destruction of?

Answer 5

Worms, tumor cells, virus infected cells

Question 6

What cells does ADCC recruit?

Answer 6

Eosinophils, basophils, neutrophils, NK cells

Question 7

ADCC is similar in functionality to what process?

Answer 7

Opsonization

Question 8

What Ig is involved in opsonization?

Answer 8

IgG

Question 9

What Igs participate in agglutination?

Answer 9

IgG, IgM, sIgA

Question 10

What is the function of agglutination?

Answer 10

Precipitates antigen out of fluids and enhances the efficient of phagocytosis

Question 11

What Igs participate in the immobilization of bacteria?

Answer 11

IgG, IgM, sIgA

Question 12

How does antibody binding immobilize bacteria?

Answer 12

Fab binds epitope on flagella protein

Question 13

What Igs can activate complement?

Answer 13

IgG, IgM

Question 14

What Igs participate in the neutralization of toxins and venoms?

Answer 14

IgG

Question 15

Which Igs can block the attachment of microbes to their target cells?

Answer 15

IgG and sIgA

Question 16

What is the major Ig responsible for the memory response?

Answer 16

IgG

Question 17

How many subclasses does IgG have?

Answer 17

4 (1,2,3,4)

Question 18

What form of IgM is found in the serum?

Answer 18

Pentameric IgM

Question 19

Which Ig is responsible for type 1 hypersensitivity?

Answer 19

IgE

Question 20

Which Ig is the best agglutinator and activator of complement?

Answer 20

IgM

Question 21

Which Ig can cross the placenta?

Answer 21

IgG

Question 22

Which Igs have a hinge region?

Answer 22

IgG, IgA, IgD

Question 23

Where is the hinge region located?

Answer 23

Between CH1 and CH2

Question 24

What amino acid is the hinge region rich in?

Answer 24

Proline

Question 25

Which Ig is the first to be produced in a primary response?

Answer 25

IgM

Question 26

Where is the monomeric form of IgM found?

Answer 26

Membrane bound to B cells

Question 27

B cell receptors generally do not bind this kind of epitope

Answer 27

Internal

Question 28

This Ig is abundant in mucus

Answer 28

IgA

Question 29

Which antibodies have a J chain?

Answer 29

Dimeric IgA and pentameric IgM