Innate Immune System Flashcards
(23 cards)
Where are PAMPs found?
On pathogen
What does PAMP stand for?
Pathogen-associated molecular patterns.
What receptors recognize PAMPs?
PRRs.
What are PRRs?
Patter-recognition receptors.
What do PRRs trigger after binding PAMPs?
Phagocytosis or other responses
The two types of inflammatory responses are
Acute and chronic
What are the 4 hallmarks of acute inflammation?
Rubor, tumor, calore, dolore
Rubor
Redness
Tumor
Swelling
Calore
Heat
Dolore
Pain
Inflammation include recruitment of what to the injured area?
Phagocytes
What phenomena cause the aforementioned hallmarks of acute inflammation?
Vasodilation and increased vascular permeability
What are the 4 steps of extravasation?
- Rolling 2. Activation 3. Arrest/adhesion 4. Transendothelial migration
What is responsible for slowing leukocytes down in the rolling phase of extravasation?
ε-selectin on endothelial cells binding mucin on leukocytes
What contributes to an antigen’s immunogenicity?
Foreignness (phylogenetic distance), molecular size, chemical composition (irregular)
What is an example of an immunogenic polysaccharide?
Blood groups (ABO)
Immunogens must be typographically accessible for which receptor?
B cell receptor
Immunogens must be digestible for which receptor?
T cell receptor
What interactions are present between Ag epitope and Ab paratope?
Noncovalent, hydrophobic.
Describe the geometry between paratope and epitope.
Complementary.
Internal epitopes may be recognized by which receptor?
TCR
What occurs when 2 different Ag share some of the same epitopes?
Immunological cross reactivity
