Antibodies- types+functions Flashcards Preview

PA2203- Mod 6 > Antibodies- types+functions > Flashcards

Flashcards in Antibodies- types+functions Deck (17)
Loading flashcards...
1
Q

What are the parts of an antibody

A

can have 5 different classes

FAB- part that attaches to antigens
FC region- tail region that determine the effector function

2
Q

IgM has how many binding sites

A

released as a multimers with >2 binding sites

3
Q

What part of the antibody attaches to the target cell

A

Antibody attaches to fc receptor on target

4
Q

What is the main antibody isotype found in blood, mucosa and in allergies

A

blood- IgG

mucosa- IgA

Allergies- IgE

5
Q

What 2 antibody classes are responsible for neutralization of microbes

A

IgA

IgG

6
Q

How do neutralizing antibodies work

A

Antibodies will coat an antigen (ex virus) and prevent it from attaching to relevant molecules/receptors

7
Q

What 2 antibodies activate classical compliant pathway

A

IgM

IgG

8
Q

What occurs in the classical complement pathway

A

Compliment pro 1 (C1q) on antigen surface will attach w antibody

9
Q

What is the functions of the classical complement path (3)

A
  1. Inflammation and chemotaxix
  2. Opsonization- tags microbes
  3. Membrane attack complex- Forms pores on microbe
10
Q

What class of antibody performs antibody mediated ozonization

A

IgG

11
Q

How does antibody mediated ozonization occur

A

IgG tags microbe and phagocytes recognize FC region of antibodies and bind

12
Q

What class of antibodies performs antibody dependent cell mediated cytotoxicity

A

IgG

13
Q

What occurs in antibody dependent cell mediated cytotoxicity

A

FAB section of antibody attaches to infected cell and FC part is recognized by NK cells (which release perforin and granzymes)

  • must be cross linked
14
Q

What antibody is responsible for mast cell activation

A

IgE

-causes mast cells to release contents

15
Q

How do B cells become antigen presenting cells

A

Internalize antigens and are loaded on MHC2 or 1 molecules and migrate to t cell zone and can activate them

16
Q

What are the 2 types of thymus independent b cells and what antibody do they secrete

A
  1. B-1 cells
  2. marginal zone b cells

Secrete IgM
do not require t cell activation

17
Q

What type of antigen are t independent b cells crucial for generating a response against

A

Against carbohydrate antigens