Antibodies- types+functions Flashcards
What are the parts of an antibody
can have 5 different classes
FAB- part that attaches to antigens
FC region- tail region that determine the effector function
IgM has how many binding sites
released as a multimers with >2 binding sites
What part of the antibody attaches to the target cell
Antibody attaches to fc receptor on target
What is the main antibody isotype found in blood, mucosa and in allergies
blood- IgG
mucosa- IgA
Allergies- IgE
What 2 antibody classes are responsible for neutralization of microbes
IgA
IgG
How do neutralizing antibodies work
Antibodies will coat an antigen (ex virus) and prevent it from attaching to relevant molecules/receptors
What 2 antibodies activate classical compliant pathway
IgM
IgG
What occurs in the classical complement pathway
Compliment pro 1 (C1q) on antigen surface will attach w antibody
What is the functions of the classical complement path (3)
- Inflammation and chemotaxix
- Opsonization- tags microbes
- Membrane attack complex- Forms pores on microbe
What class of antibody performs antibody mediated ozonization
IgG
How does antibody mediated ozonization occur
IgG tags microbe and phagocytes recognize FC region of antibodies and bind
What class of antibodies performs antibody dependent cell mediated cytotoxicity
IgG
What occurs in antibody dependent cell mediated cytotoxicity
FAB section of antibody attaches to infected cell and FC part is recognized by NK cells (which release perforin and granzymes)
- must be cross linked
What antibody is responsible for mast cell activation
IgE
-causes mast cells to release contents
How do B cells become antigen presenting cells
Internalize antigens and are loaded on MHC2 or 1 molecules and migrate to t cell zone and can activate them
What are the 2 types of thymus independent b cells and what antibody do they secrete
- B-1 cells
- marginal zone b cells
Secrete IgM
do not require t cell activation
What type of antigen are t independent b cells crucial for generating a response against
Against carbohydrate antigens
