Intro to Immune system Flashcards Preview

PA2203- Mod 6 > Intro to Immune system > Flashcards

Flashcards in Intro to Immune system Deck (16)
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1
Q

Iniate immunity- found in, timing, major cells involved + types of receptos

A
  • In most living organisms
  • Rapids (mins to days)
  • Parynchymal cells, granulocytes, lymphoid cells, monocytes, macrophages, dendritic cells
  • Pattern recognition receptors (non spec)
2
Q

Cellular vs horomonal immunity

A

cellular- cell based components of immune system (macrophages, neutrophils, tcells)

humoral- extracellular components (complement pro, antibodies)

3
Q

what are the 2 main lymphoid organs (and what is produced there)

A

Bone marrow- multipotent stem cells, B cell development

Thymus- Site of t cell development

4
Q

what are the 3 main secondary lympoid organs (+ what happens there)

A
  1. Lymph nodes
  2. Spleen
  3. MALTS (NALT/BALT/GALT, Peyers patches, tonsils, apendix)

Site of activation of T/B cells

5
Q

Functions of Lymphatic system (3)

A
  1. Removal of excess fluids in body tissues
  2. Absorbtion of fatty acifs
  3. Immune defence (transport b/t cells)
6
Q

where are t and b cells found in the lymph node

A

Paracortical area- mostly t cells

Germinal centers- where b cells are found

7
Q

What happens in the two pulps of the spleen

A

Red- site of RBC removal, monocyte resevoir

White- Peripheral lymphoid tissue (where t + B cells activated)

8
Q

What are the organized MALTs (and loc)

A

Payers patches- in ileum of s. intestine

Tonsils

9
Q

What are the sporatic MALTs

A

NALT
GALT
VALT

10
Q

What is waldeyes ring and what is it made of

A

-located post to opening of the eustachian tube on lat wall of nasopharynx

  1. Adenoid
  2. tubal
  3. palantine
  4. Lingual
11
Q

What are tertiary lymphoid organs

A

Pathological lymph node-like structures that form in tissues at sites of chronic inflammation

12
Q

what are the 3 major categoiries of soluble mediators of immunity

A
  1. Cytokines (ILs, Chemokines, Interferons, TNFa)
  2. Lipid mediators (protaglandins, leukotriens)
  3. Vasoactive amines (histamine, serotonin)
13
Q

Function of IL1, TNFa, IL6, IL8 and IL12

A

IL1/TNFa- Activates vascular endothelium
IL6- Local and systemic effects
IL8- Chemokine
IL12- Activation of NK cells

14
Q

Antigen vs epitope

A

Antigen- a substance that induces the immune response

epitope- The specific part of the antigen which B and T cells recognize

15
Q

What are the 2 Antigens and what part of the immune system recognizes them

A

DAMPS- antigens associates with cell injury

PAMPS- Antigens found soley on harmfull microbes (pathogens)

Innate system prioritizes PAMP/DAMP detection

16
Q

what are the cells part of the common lympoid progenitor lineage

A

B/T cells
NK cells
Myleoblasts (basophils, monocytes etc)
MAST cells `