Antibotics Exam 3 Flashcards Preview

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Flashcards in Antibotics Exam 3 Deck (14)
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1

Minimal Inhibitory Concentration (MIC)

The minimum drug conc. at which the bacterial population is inhibited to prevent visual growth.

2

Minimal Bactericidal Concentration (MBC)

The minimum drug conc. at which the bacterial population is killed.

3

What antimicrobial is the most toxic to humans?

Natural antibiotics are more toxic and less effective. Synthetic are loss toxic and more effective.

4

True or False? All antibiotics are antimicrobials, but not all antimicrobials are antibiotics.

True.

5

Broad spectrum antibacterials are effective against...
List the examples.

Gram pos and Gram neg
tetracyclines, phenicols, fluroquinolones, 3rd and 4th generation cephalosporins.

6

Glycopeptides and bacitracin are only effective against...

Gram pos bacteria

7

Polymixins are effective against....

Only gram neg bacteria

8

Aminoglycosides and sulfonamides are effective against...

Aerobic organisms

9

Nitroimidazoles are effective against...

Anaerobes.

10

What are the antibiotics classified into?
List them.

Function.
Inhibits cell wall synthesis, protein synthesis, membrane function, DNA/RNA synthesis, and various metabolic processes.

11

What is beta-lactams classified into?

Inhibits cell wall synthesis

12

List antibiotics that are beta-lactams

penicillin, cephalosporins, monobactams, carbapenems, glycopeptides, fosfomycins. *Have to have a cell wall unlike Mycoplasma and Ureaplasma*

13

What 2 amino acids form the beta-lactam ring?

Valine and Cysteine.

14

How do the Beta-lactams work?

BL ring binds to penicillin binding protein. Antibiotic binding to PBP inhibits their actions.