Anticholinergics Flashcards Preview

RT104A-Pharmacology > Anticholinergics > Flashcards

Flashcards in Anticholinergics Deck (18):
1

KT: anticholinergic bronchodilator

agent that blocks parasympathetic nervous fibers, which allow relaxation of smooth muscle in the airways

2

KT: antimuscarinic bronchodilator

same as anitcholinergic broncodilator—agent that blocks the effectof Ach at the cholinergic site

3

KT: cholinergic/muscarinic

agent that produces the effect of Ach

4

KT: parasympatholytic

blocking parasympathetic nervous fibers

5

KT: parasympathomimetic

producing effects similar to the parasympathetic nervous system

6

Clinical indications for use of an anticholinergic bronchodilator

COPD maintenance
acute exacerbation

7

Clinical indication for anticholinergic and β-agonist bronchodilators

COPD + airway obstruction

8

Atropine

Anticholinergic, Parasympatholytic, Antimuscarinic
Not recommended for inhalation

9

Ipatropium bromide

Anticholinergic, Parasympatholytic, Antimuscarinic
Atrovent HFA - HFA MDI, SVN, Nasal Spray
Onset: 15 min; Peak: 1-2 hr; Duration: 4-6 hr

10

Ipatropium bromide + Albuterol

Combination of a anticholinergic and β2-agonist
Combivent - MDI
Duoneb - SVN
Onset: 15 min; Peak: 1-2 hr; Duration 4-6 hr

11

Tiotropium bromide

Anticholinergic, Parasympatholytic, Antimuscarinic
Spiriva - DPI
Selective for M1 & M3 receptor types
Onset: 30 min; Peak: 1-3 hr; Duration: 24 hr

12

Glycopyrrolate

not something we really use
not approved for inhalation
used parenterally to reverse neuromuscular blockade

13

Aclidinium bromide

Anticholinergic, Parasympatholytic, Antimuscarinic
Tudorza Pressair -DPI
Currently being developed by Forest Laboratories
log-acting anticholinergic bronchodilator

14

Pharmacologic effects of anticholinergics

increased HR, pupil dilation, drying of airways, slows mucus production, inhibits constriction

15

M1 receptor

-parasympathetic ganglia
-facilitate neurotransmission and bronchoconstriction
-cause secretion and rhinitis in nose

16

M2 receptor

-inhibit continued use of Ach
-blockade may enhance Ach release, conteracting bronchodilation

17

M3 receptor

-smooth airway muscle
-cause bronchoconstriction
-cause secretion and rhinitis in nose

18

Side of Effects of Anticholinergics

Dry mouth (most common); Mydriasis; SVN: pharyngitis, dyspnea, flulike symtpoms, bronchitis, upper resp. infection