Beta-Agonists Flashcards Preview

RT104A-Pharmacology > Beta-Agonists > Flashcards

Flashcards in Beta-Agonists Deck (25):
1

Salmeterol

Sympathomimetic, Adrenergic, β2-agonist
Serevent Diskus (β2)-DPI
LABA
Onset: 20 min; Peak: 3-5 hrs; Duration: 12 hours

2

Albuterol (5)

Sympathomimetic, Adrenergic, β2-agonist, Saligenin
Proventil, Proair, Accuneb, VoSpire ER (β2) - SVN, MDI, TAB, Syrup
SABA
(VoSpire ER = extended release)
Onset: 15 min; Peak: 30-60 min; Duration 5-8 hrs

3

Arformoterol

Sympathomimetic, Adrenergic, β2-agonist
Brovana (β2) - SVN
LABA
Onset: 15 min; Peak: 30-60 min; Duration: 12 hr

4

Isoetharine

Sympathomimetic, Adrenerguc, β2 agonist, Catecholamine
Bronkosol (β2)

5

Pirbuterol

Sympathomimetic, Adrenergic, β2-agonist
Maxair Autohaler (β2) - MDI
SABA
Onset: 5 min; Peak: 30 min; Duration 5 hr

6

Metaproteranol

Sympathomimetic, Adrenergic, β2-agonist, Resorcinol
Alupent (β2) - SVN, TAB, Syrup
SABA
Onset: 1-5 min; Peak: 60 min; Duration 2-6 hr

7

Racemic Epinephrine

Sympathomimetic, Adrenergic, β2-agonist, Catecholamine
Micronefrin (α, β) - SVN
Ultra SABA
Onset: 3-5 min; Peak: 5-20 min; Duration: 0.5-2 hr

8

Isoproterenol

Sympathomimetic, Adrenergic, β2-agonist, Catecholamine
Isuprel (β1 & β2)
Not available through nebulizer solution, available parenterally

9

Vilanterol

Sympathomimetic, Adrenergic, β2-agonist
LABA
Only approved in the U.S. in combination w/ fluticasone furoate as BREO ELLIPTA

10

Indacaterol

Sympathomimetic, Adrenergic, β2-agonist
Arcapta Neohaler
LABA

11

Epinephrine

Sympathomimetic, Adrenergic, β2-agonist, Catecholamine
Adrenaline chloride, Primatene Mist (α, β) - SVN, MDI
Ultra SABA
Onset: 3-5 min; Peak: 5-20 min; Duration: 1-3 hr

12

Fomoterol (3)

Sympathomimetic, Adrenergic, β2-agonist
Foradil, Centihaler, Perforomist (β2) - SVN, DPI
LABA
Onset: 15 min; Peak: 30-60 min; Duration: 12 hr

13

Bitolterol

Sympathomimetic, Adrenergic, β2-agonist
Tornalate
Removed from the market
Prodrug

14

Levalbuterol

Sympathomimetic, Adrenergic, β2-agonist
Xopenex (β2) - SVN, MDI
SABA
Only has the (R)-isomer
Onset: 15 min; Peak: 30-60 min; Duration: 5-8 hr

15

KT: Adrenergic Bronchodilator

agent that stimulates sympathetic nervous fibers, which allow relaxation of smooth muscle in the airway. aka sympathomimetic bronchodilator or β2-agonist

16

KT: α-receptor stimulation

causes vasoconstriction and vasopressor effect; in the upper airway, this can provide decongestion

17

KT: asthma paradox

the increasing incidence of asthma morbidity, and esp. asthma mortality, despite advances in the understanding of asthma and availability of improved drugs to treat asthma

18

KT: β1-receptor stimulation

causes increased myocardial conductivity and increased heart rate as well as increased contractile force

19

KT: β2-receptor stimulation

causes relaxation of bronchial smooth muscle, with some inhibition of inflammatory mediator release and stimulation of mucociliary clearance

20

KT: bronchospasm

narrowing of the bronchial airways, caused by contraction of smooth muscle

21

KT: catecholamines

group of similar compounds having sympathomimetic action, they mimic the actions of epinephrines

22

KT: downregulation

nucleotide produced by long-term desensitization of β receptors to β2-agonists, caused by a reduction in the number of β receptors

23

KT: prodrug

drug that exhibits its pharmacologic activity when it is converted, inside the body, to its active form

24

KT: sympathomimetic

producing effects similar to those of the sympathetic nervous system

25

β-adrenergic can effect V/Q ratio

Leads to a decreased PaO2 and increase in PaCO2