Methylxanthines Flashcards Preview

RT104A-Pharmacology > Methylxanthines > Flashcards

Flashcards in Methylxanthines Deck (11):
1

KT: alkaloids

group of alkaline substances taken from plants, which react w/ acids to form salts

2

KT: methylxanthines

chemical group of drugs derived from xanthines

3

KT: phosphodiesterase (PDE)

group of enzymes that change intracellular signaling

4

KT: xanthine

nitrogenous compound found in many organs and in the blood and urine

5

Uncontrolled asthma

asthma more than 2x a week requiring medication

6

Clinical Indications for Use of Xanthines...

Asthma (Theophylline)
COPD (Theophylline: recommended as an alternative to β2 agonist & anticholinergic)
Apnea of Prematurity: first line treatment, Theophylline most often used, caffeine citrate may be better choice

7

Serum levels of Theophylline

No effects seen: 20 mcg/mL
Cardiac arrythmias: >30 mcg/mL
Seizures: 40-45 mcg/mL

8

Theophylline

Slo-Phyllin, Theolair, Quibron, Bronkodyl, Theo-dur

9

Aminophylline

Aminophylline

10

Serum level of theophylline to treat asthma

5-15 mcg/mL

11

Serum level of theophyliine to treat COPD

10-12 mcg/mL