anticoagulants Flashcards
(45 cards)
hemostasis
vascular injury, collagen exposed, vwf anchors plt to collagen
- Prothrombin–>thromin IIA which activates platelets
- thrombin IIA releases mediators TX2 and ADP which promote and uncover fibrinogen (I) and continues plt aggregating
- ADP and TX2 activate more platelets and proteins impt for cascase
- fibrin mesh clot formed (XIII)
TX2 and ADP do what
promotes plt aggregation, uncovers fibrinogen, and activates proteins for cascade
what blocks tx2
aspirin
what activates thromin
prothrombin
where are anticoag factors produced
liver except tissue factor, ca++ and VWF
where is VIII:VWF produced
vascular endothelium
where is tissue factor (III) produced
injured ells
where is ca++ produced
from diet
vit k dependent factors
II, VII, IX, X, protein C and S
Pt measures
extrinsic pathway
end result extrinsic pathway
activation of factor X
extrinsic pathway factos
III (tissue factor), VII and calcium- you can by the extrinsic pathway for .37c
primary initiator coag cascade
tissue factor
what happens intinsic
tissue factor—>VII—>V
VWF
most common inherited dysfunction, tx ddavp, ffp
what inhibit adp
ticlid, plavix, persantine
what inhibit GB IIA, IIIA
integrilling, reopro, aggrastat
ptt measures
intrinsic pathway
factors in intrinsic
XII, XI, IX, VIII- you can by the intrinsic pathway for $12 or $11.98
what happens in intrinsic pathway
XII—>XI—>IX—>X
common pathway factors
V, X, I, II, XII- you can buy the common pathway at a 5 and dime for 1 or 2 dollars on 13th of each month
antithrombin inhibits
factors IIA and Xa, partially inhibits factors IXa, XIa, XIIa
heparin
required cofactor for heparin, binds to and enhances antithrombin by 1000x
warfarin
inhibits clotting factor synthesis
