Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

peripheral vasodilators2 > tricyclic antibiotics 2 > Flashcards

tricyclic antibiotics 2 Flashcards

(79 cards)

Start Studying
1
Q

how long for therapeutic effect tricyclics? ssri?

A

2-3 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

mech action tca

A

unknown, inhibits norepi neuronal uptake mild 5-h serotonin receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

metabolism tca

A

liver, 1/2 life is 8-84hr, large vol distribution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

s/e TCA

A

orthostatic hypotension, tachycardia, tachy, blurred vision, dry mouth, sedation, delirium, tremors, weight gain, neurolepitc malignant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

cns toxicity tca s/s

A

cognitive, motion, psych changes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

overdose tCA-

A

fatal arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

SSRIs mech action

A

modulate serotonin neurons in the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

s/e ssris

A

no anticholinergic/cardiac s/e, nausea, vomiting, anxiety, insomnia, weight loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

1/2 life ssri

A

2-3 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MAOIs

A

ihibit MAO-A and MAO-B but action at MAO-a, which inhibits metabolism of norepi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

s/e maois

A

hepatotoxic,cardiac toxic with tyrosine, tremors, orthostatic htn, hyperpyrexia with certain meds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

trazodone

A

mech unknown

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

s/e trazodone

A

no muscarinic effects, CNS stim with insomnia, tremors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

contraindications trazodone

A

seizures and head trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

lithium

A

replaces sodium at certain synapses mood stabilizer, narrow therapeutic window

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

s/s lithium toxicity

A

n,v,diarrhea, abd pain, polyuria, sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what may occur with chronic lithum use?

A

hypothyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

antipsych meds do what

A

block dopamine in the brain which is therapeutic at the mesolimbic-mesocortical system but the nigostraital system causes extrapyrimidial side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

s/e antipsychotics

A

sedation secondary to histamine release, extrapyradamidal side effects (acute dystonia, akathisa, parkinsonism, tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what is a late, occuring s/e of antipsychotics

A

tardive dyskinesia- usually irreversible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

how do you treat acute dystonia

A

treat with congentin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

how do you treat akathisia

A

benzo/beta block

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

s/s neuroleptic malignant syndrome

A

fever, diffuse muscle pain, severe eps, autonomic dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

tx neuroleptic malignant syndrome

A

tx with parlodel, cooling, hydration, dantrium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
s/e antipsychotics
postural hypotension, hyperprolactinemia, jaundice, corneal opacities, photosensitivity, agranulocytosis
26
contraindications antipsych
parkinsons, hepatic failure, bone marrow dep
27
whoch meds do pt on antipsychotics respond to better?
norepi vs. epi with hypotension
28
levodopa/carbidopa is for
tx parkinsons, considered replacement therpy, precuror of dopamine
29
levodopa is
an amino acid, transported across bbb and converted to dopamine by the enzyme L-aromatic amino acid decorboxylase
30
why is carbidoba given with levodopa?
carbidopa blocks conversion of levodopa to dopamine in the periphery b/c carbidopa is there, but cannot cross bbb. if not pt would have hypertensive crisis secondary to carbidopa which increases blood pressure
31
prob with pt with parkinsons
not enough dopamine, which is necessary for movement. insufficient amount makes them not able to move
32
where is carbiopa activated and what is it
decarboxylase inhibitor, ative liver, kidney, gi
33
which symptoms improve first with levo/carbo
rigidit and bradykinesia before tremor
34
s/e levo/carbo
nausea, vomiting, anorexia, secondary to ctz activation in the area postrema in the medulla by dopamine, orthostatic hypotension adn cardiac arrhythmias by beta dopamine stim
35
2nd set side effects levo/dop after long term therapy
abn movement of limbs, hands, trunk, tongue, serious mental disturbances (drug holiday x 1 week)
36
contraindications levo/carbi
MAO inhibitors, narrow angle glaucoma, heart arrhythmias, recent MI
37
what that is given with levo/carbi can cause EPS
phenothiazines, reserpine, butyrophenones
38
selegine
first choice drug parkinsons, enhances endogenous dopamine it is an MAO-B inhibitor
39
precautions slegiline
same as MAOs
40
seleginline and tcas
fever, agitation, delirium, coma
41
belladonna alkaloids
mild parkinsons, helps in drug induced dysonia
42
dopamine agonists
parlodel, permax
43
s/e dopamine agonists
anorexia, nausea
44
parkinsons and anesthesia
have pt take meds pre op, avoid phenothiazines, butyrophenones and reglan, increased risk aspiration, intravascularly vol depleted, increased risk laryngospasm
45
pt on deprenyl what drug cant give
ephedrine
46
ketamine can cause what with parkinsons
exagg symp response
47
succ and parkinsons
potential hyperkalemic response
48
anticonvulsants goal
to raise seizure threshold
49
% pt who become seizure free on anticonvulsants
40%
50
anticonvulsants mech of action
sodium channel blockers, block the sustained high frequency repetitive firing of action potentials
51
type I anticonvuls
enhance sodium channel inactivation
52
type I anticonvulsant meds
phenytoin, carbamezepine, oxcarbazepine, lamotrigine, felamate
53
type II anticonvulsants
enhance gaba inhibition, reduce t calcium currents, block ssustained high freq repetitive firins
54
type II anticonvulsant drugs
valproic acid, benzos, phenobarb, primidone,
55
type III anticonvulsants
block T calcium channels only
56
type of type II anticonvulsants
ethosuximide, trimethadione
57
type IV anticonvulsants
only enhances GABA inhibtition
58
type of type IV anticonfulsants
vigabatrin
59
noncategorized anticonvulsents
no effect on any known causes
60
drugs asso with noncat.
gabapentin
61
dilantin treats
tonic-clonic seizures and partial
62
dilantin is metabolized by
zero order kinetics which leads to induction of hepatic micorsomal enzymes
63
dilantin and protein binding
highly
64
s/e dilantin
gingival hyperplasia, enlargement lips and nose, fetal hydantoin syndrome, folate def
65
acute overdose diantin signs
nystagmus, ataxia, vertigo, diplopia, cognitive changes
66
drug interactions dilantin
cimetidine, chloramphenicol, disulfram, isoniazid
67
tegretol type of seizures treated
tonic-clonic and abcesnse
68
common side effect tegretol
drowsiness
69
what will tegretol do with metaboism
increase rate of metabolism of other anticoags
70
barbiturates mech action
facilitation of GABA inhibition
71
main side effect barbs
sedation
72
all anticonvulsants bascially cause
hepatic microsomal enzyme
73
depakene mech action
blockage sodium channels that are voltage dependent, cause increase brain GABA
74
s/e Depakene
hepatotoxicity, fetal neural tube defects, alopecia
75
benzos mech action
interaction with GABA- not first line therapy
76
administer phenytoin rate
25-50mg/min to avoid hypotension
77
phenytoin causes
resistance to NBMR
78
what can phenytoin cause
stevens johnson syndrome
79
people on anticonvulsants show
a toleratnce to opiods secondary to enzyme activation caused by anticonvulsant

peripheral vasodilators2 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions