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Flashcards in Anticoagulation Labs Deck (36)
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1

High citrate concentration in tube

Affects anti-factor Xa

2

Poor blood samples

Increase both anti-factor Xa and aPTT

3

Underfilled tubes

Increase aPTT

4

Prolonged time > 2 hours to sample analysis

Decrease both anti-factor Xa and aPTT

5

Inadequate centrifugation

Decrease both anti-factor Xa and aPTT

6

Antithrombin deficiency

Decrease both anti-factor Xa and aPTT

7

Increased acute phase reactants like factor 8 and fibrinogen

Decrease aPTT

8

Increased heparin binding proteins

Decrease both anti-factor Xa and aPTT

9

Obesity

Decreases both anti-factor Xa and aPTT

10

Decreased renal elimination

Increase both anti-factor Xa and aPTT

11

Decreased clotting factors (liver disease)

Increase aPTT

12

Consumptive coagulopathy (DIC)

Increase aPTT

13

Lupus anticoagulant

Increase aPTT

14

Decreased clotting factors (Not factor 8)

Increase aPTT

15

Elderly

Increase aPTT

16

Recent use of other anti-Xa meds

Increase anti-factor Xa

17

High triglycerides

Increase anti-factor Xa

18

High bilirubin

Decrease anti-factor Xa

19

COVID-19

Increase aPTT

20

Should you wait for anti-Xa and aPTT baseline labs to result before starting a heparin infusion?

No, infusion should be started immediately and lab results can later influence dosing

21

After a heparin infusion starts, when do you measure an anti-Xa level

4 - 6 hours after an infusion starts or infusion rate change without a bolus

22

If a heparin bolus is given that is < 2500 units, when do you measure an anti-Xa level

6 hours after

23

Since anti-Xa heparin assay is a chromogenic test, erroneous results can come from patients that have

Hemolysis, icterus, lipema (basically anything that affects how the blood looks)

24

Anti-Xa heparin assay vs. Factor X assay

Anti-Xa heparin assay detects heparin's effect of the patient's plasma based on inhibition of factor X in an assay reagent; Factor X assay measures a patient's endogenous level of functional Factor X

25

What tests measure dabigatran?

Ecarin clotting assay, dilute thrombin time, or thrombin time

26

What test measures enoxaparin?

Anti-Xa LMWH assay

27

What is hematocrit?

Percent of red blood cells in the blood

28

What is hemoglobin?

Presence of oxygenated blood

29

What is d-dimer?

Product of fibrin degeneration

30

What is a d-dimer determining?

If a d-dimer is negative, patient likely does not have a VTE. If a d-dimer is positive, do more tests.