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Flashcards in Stroke 2014: Stroke Prevention Deck (7)
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If stroke/TIA caused by 50 - 99% stenosis of a major intracranial artery, preferred antithrombotic therapy is

Aspirin 325 mg > warfarin


When is it reasonable to start anticoagulation after the onset of neurological symptoms?

Within 14 days (2 weeks)

Unless high risk hemorrhagic conversion in which case it is reasonable to delay initiation beyond 14 days


If stroke/TIA within 30 days, what agent, dose, and duration can be added on to ASA (if 70 - 99% stenosis of a major intracranial artery)

Clopidogrel 75 mg daily for 90 days


If mechanical valve + history of stroke/TIA prior to its insertion + low bleeding risk, recommended antithrombotic therapy is

warfarin + ASA 81 mg daily


If mechanical valve + stroke/TIA after antithrombotic therapy, depending on bleeding risk, it is reasonable to

Intensify therapy by increasing target INR or increasing ASA dose to 325 mg


If noncardioembolic ischemic stroke or TIA, antithrombotic agents of choice

antiplatelet agents over oral anticoagulants


Although rtPA is an approved treatment for acute ischemic stroke, it is best given if

On warfarin and INR is below 1.7
Dabigatran with a normal aPTT and last intake > 48 hours previously

"Systemic thrombolysis is contraindicated in patients on therapeutic OAC." -2016