Antidepressant/Stimulant Drugs

Question 1

Amitriptyline

1) Use
2) Mechanism of Action

Answer 1

1) Depression
2) Tricyclic Antidepressant (TCA)-inhibits NE transporter (NET) and Serotonin transporter (SERT)
* Metabolized by CYP2D6*

Question 2

Nortriptyline

1) Use
2) Mechanism of Action

Answer 2

1) Depression
2) Tricyclic Antidepressant (TCA)-inhibits NE transporter (NET) and Serotonin transporter (SERT)
* Metabolized by CYP2D6*

Question 3

Imipramine

1) Use
2) Mechanism of Action

Answer 3

1) Depression
2) Tricyclic Antidepressant (TCA)-inhibits NE transporter (NET) and Serotonin transporter (SERT)
* Metabolized by CYP2D6*

Question 4

Amoxapine

1) Use
2) Mechanism of Action

Answer 4

1) Depression
2) Tricyclic Antidepressant (TCA)-inhibits NE transporter (NET) and Serotonin transporter (SERT)
* Metabolized by CYP2D6*

Question 5

Fluoxetine

1) Use
2) Mechanism of Action

Answer 5

1) Depression

2) Selective Serotonin Reuptake Inhibitors (SSRIs)-inhibit Serotonin transporters (SERTs)

Question 6

Citalopram

1) Use
2) Mechanism of Action

Answer 6

1) Depression

2) Selective Serotonin Reuptake Inhibitors (SSRIs)-inhibit Serotonin transporters (SERTs)

Question 7

Escitalopram

1) Use
2) Mechanism of Action

Answer 7

1) Depression

2) Selective Serotonin Reuptake Inhibitors (SSRIs)-inhibit Serotonin transporters (SERTs)

Question 8

Sertraline

1) Use
2) Mechanism of Action

Answer 8

1) Depression

2) Selective Serotonin Reuptake Inhibitors (SSRIs)-inhibit Serotonin transporters (SERTs)

Question 9

Paraxetine

1) Use
2) Mechanism of Action

Answer 9

1) Depression
2) Selective Serotonin Reuptake Inhibitors (SSRIs)-inhibit Serotonin transporters (SERTs)
* Metabolized by CYP2D6*

Question 10

Venlafaxine

1) Use
2) Mechanism of Action

Answer 10

1) Depression
2) Serotonin Norepinephrine Reuptake Inhibitor (SNRIs)-inhibits NE transporters (NETs) and Serotonin transporters (SERTs)
* Metabolized by CYP2D6*

Question 11

Desvenlafaxine

1) Use
2) Mechanism of Action

Answer 11

1) Depression
2) Serotonin Norepinephrine Reuptake Inhibitor (SNRIs)-inhibits NE transporters (NETs) and Serotonin transporters (SERTs)

Question 12

Duloxetine

1) Use
2) Mechanism of Action

Answer 12

1) Depression
2) Serotonin Norepinephrine Reuptake Inhibitor (SNRIs)-inhibits NE transporters (NETs) and Serotonin transporters (SERTs)
* Metabolized by CYP2D6*

Question 13

Levomilnacipram

1) Use
2) Mechanism of Action

Answer 13

1) Depression
2) Serotonin Norepinephrine Reuptake Inhibitor (SNRIs)-inhibits NE transporters (NETs) and Serotonin transporters (SERTs)

Question 14

Phenelzine

1) Use
2) Mechanism of Action

Answer 14

1) Depression
2) Monoamine Oxidase Inhibitor (MAOI)-IRREVERSIBLY blocks monoamine oxidase causing increased monoamine (NE, Serotonin, Dopamine) signaling
* Serotonin Syndrome & “Cheese” Effect*

Question 15

Tranylcypromine

1) Use
2) Mechanism of Action

Answer 15

1) Depression
2) Monoamine Oxidase Inhibitor (MAOI)-IRREVERSIBLY blocks monoamine oxidase causing increased monoamine (NE, Serotonin, Dopamine) signaling
* Serotonin Syndrome & “Cheese” Effect*

Question 16

Selegiline

1) Use
2) Mechanism of Action

Answer 16

1) Depression
2) Monoamine Oxidase Inhibitor (MAOI)-IRREVERSIBLY blocks monoamine oxidase causing increased monoamine (NE, Serotonin, Dopamine) signaling
* Serotonin Syndrome & “Cheese” Effect*

Question 17

Isocarboxazid

1) Use
2) Mechanism of Action

Answer 17

1) Depression
2) Monoamine Oxidase Inhibitor (MAOI)-IRREVERSIBLY blocks monoamine oxidase causing increased monoamine (NE, Serotonin, Dopamine) signaling
* Serotonin Syndrome & “Cheese” Effect*

Question 18

Bupropion

1) Use
2) Mechanism of Action

Answer 18

1) Depression
2) Atypical Antidepressant-Blocks the Dopamine transporters (DATs)
* Metabolized by CYP2D6*
* Used in combo w/TCAs

Question 19

Trazodone

1) Use
2) Mechanism of Action

Answer 19

1) Depression
2) Atypical Antidepressant-Blocks the Serotonin transporters (SERTs)
* Metabolized by CYP2D6*
* Used in combo w/TCAs

Question 20

Nefazodone

1) Use
2) Mechanism of Action

Answer 20

1) Depression
2) Atypical Antidepressant-Blocks the Serotonin transporters (SERTs) and 5-HT2a Serotonin receptors
* Used in combo w/TCAs

Question 21

Mirtazapine

1) Use
2) Mechanism of Action

Answer 21

1) Depression
2) Atypical Antidepressant-Blocks alpha2 receptors on preganglionic NE and Serotonin neurons to inhibit negative feedback mechanism and increase release of NE and Serotonin
* Metabolized by CYP2D6*
* Used in combo w/TCAs

Question 22

Lithium Salts

1) Use
2) Mechanism of Action

Answer 22

1) Bipolar
2) Unknown
* Low therapeutic index=toxicEspecially Kidney toxicity

Question 23

Amphetamine

1) Use
2) Mechanism of Action

Answer 23

1) ADHD, Narcolepsy
2) Inhibit MAOs, Release monoamines from vesicles into cytoplasm of presynaptic terminal, and reverse the polarity of NE and Dopamine transporters

Question 24

Methylphenidate

1) Use
2) Mechanism of Action

Answer 24

1) ADHD, Narcolepsy
2) Inhibit MAOs, Release monoamines from vesicles into cytoplasm of presynaptic terminal, and reverse the polarity of NE and Dopamine transporters

Question 25

Dextroamphetamine

1) Use
2) Mechanism of Action

Answer 25

1) ADHD, Narcolepsy
2) Inhibit MAOs, Release monoamines from vesicles into cytoplasm of presynaptic terminal, and reverse the polarity of NE and Dopamine transporters

Question 26

Atomexetine

1) Use
2) Mechanism of Action

Answer 26

1) ADHD

2) NE reuptake inhibitor

Question 27

Modafinil

1) Use
2) Mechanism of Action

Answer 27

1) Narcolepsy
2) Unclear-involves NE & Dopamine
* Fewer effects on mood and thinking