CNS Depressant Drugs

Question 1

Diazepam

1) Use
2) Mechanism of Action

Answer 1

1) Chronic anxiety, alcohol withdrawal, muscle relaxant

2) Benzodiazepines-bind between alpha and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent AP

Question 2

Lorazepam

1) Use
2) Mechanism of Action

Answer 2

1) Insomnia, anxiety, muscle relaxant

2) Benzodiazepines-bind between alpha and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent AP

Question 3

Alprazolam

1) Use
2) Mechanism of Action

Answer 3

1) Insomnia, Anxiety

2) Benzodiazepines-bind between alpha and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent AP

Question 4

Midazolam

1) Use
2) Mechanism of Action

Answer 4

1) Preanesthetic

2) Benzodiazepines-bind between alpha and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent AP

Question 5

Clonazepam

1) Use
2) Mechanism of Action

Answer 5

1) Anxiety

2) Benzodiazepines-bind between alpha and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent AP

Question 6

Chlordiazepoxide

1) Use
2) Mechanism of Action

Answer 6

1) Anxiety

2) Benzodiazepines-bind between alpha and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent AP

Question 7

Zolpidem

1) Use
2) Mechanism of Action

Answer 7

1) Anxiety

2) Non-Benzos- bind between alpha1 and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent APs

Question 8

Zaleplon

1) Use
2) Mechanism of Action

Answer 8

1) Anxiety

2) Non-Benzos- bind between alpha1 and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent APs

Question 9

Eszopiclone

1) Use
2) Mechanism of Action

Answer 9

1) Anxiety

2) Non-Benzos- bind between alpha1 and gamma subunits on GABAa receptor to hyperpolarize the neuron and prevent APs

Question 10

Phenobarbital

1) Use
2) Mechanism of Action

Answer 10

1) Anticonvulsant

2) Barbiturate- binds on beta subunit of GABAa receptor to hyperpolarize the neuron and prevent APs

Question 11

Propranolol

1) Use
2) Mechanism of Action

Answer 11

1) “Stage-fright”-situational anxiety

2) Inhibits beta1 and beta2 adrenergic receptors

Question 12

Buspirone

1) Use
2) Mechanism of Action

Answer 12

1) Chronic anxiety (onset takes 1-2 weeks)

2) Partial agonist for serotonin1A (5-HT1A) receptor

Question 13

Ramelteon

1) Use
2) Mechanism of Action

Answer 13

1) Sleep (reduced time to fall asleep)

2) Melatonin receptor (MT1 and MT2) agonist

Question 14

Suvorexant

1) Use
2) Mechanism of Action

Answer 14

1) Sleep

2) Orexin receptor (OX1 and OX2) antagonist- blocks wakefullness