Antidepressants Flashcards Preview

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Flashcards in Antidepressants Deck (31):
1

Tricyclic Antidepressants

Imipramine
Amitryptyline

2

SSRIs

Fluoxetine
Escitalopram
Paroxetine
Sertraline

3

SNRIs

Duloxetine
Venlafaxine

4

Serotonin 5HT2 Antagonists

Nafazodone
Trazodone

5

Heterocyclic Antidepressants

Amoxapine
Bupropion
Maprotiline
Mirtazapine

6

TCA
Blocks NE and 5HT transporters
Backup drug for MDD
Additive depression of the CNS with other central depressants

Drug?

Imipramine
(Clomipramine, Desipramine, AMITRYPTILINE, Nortryptiline)

7

TCA:
Toxic Dose: _____
Lethal Dose: _____

7mg/kg (7 tabs Imipramine 75mg)
15mg/kg (14 tabs Imipramine 75mg)

8

3 Cs of TCA Overdose

Cardiotoxicity
Coma
Convulsions

9

Tx of TCA Overdose

Supportive Therapy (Fluid resuscitation, activated charcoal, benzodiazepines)
Bicarbonate to reverse cardiotoxicity

10

SSRI
First line for MDD
SE: Erectile dysfunction, withdrawal syndrome
Serotonin Syndrome when used with MAOIs

Fluoxetine
(Paroxetine, Citalopram, Escitalopram, Sertraline, Fluvoxamine)

11

SSRIs that are CYP450 inhibitors

Fluoxetine
Fluvoxamine

12

Drugs that cause erectile dysfunction

SORE PEnis Still Fucks Hard
SSRIs
Opiates
Risperidone
Ethanol
Propranolol
Estrogen
Spironolactone
Finasteride
Hydrochlorothiazide

13

Life-threatening syndrome characterized by severe muscle rigidity, myoclonus, hyperthermia, cardiovascular instability, and marked CNS stimulatory effects including seizures

Serotonin Syndrome

14

SNRI
Alternative to SSRIs for MDD
SE: Hypertension, Hepatotoxicity, Withdrawal

Venlafaxine
(Duloxetine, Desvenlafaxine)

15

SNRI that is a CYP450 inhibitor

Venlafaxine

16

Serotonin antagonist that blocks 5HT2 receptors
SE: orthostatic hypotension, priapism, hepatotoxicity
Can cause arrhythmia in pxs with pre-existing cardiac disease

Trazodone
(Nefazodone)

17

Drugs to cause Priapism

Tigas Penis QU AyaW Bumaba
Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion

18

Tetracyclic antidepressants
Strong epinephrine reuptake inhibitor, weak serotonin reuptake inhibitor, Blocks Dopamine D2
SE: Akathisia, Parkinsonism, Amenorrhea-Galactorrhea Syndrome, Seizures, Cardiotoxicity
Lowers Seizure Threshold

Amoxapine

19

Increases amine release from nerve endings by antagonism of presynaptic alpha2 adrenoceptors, blocks 5HT2 receptors
Drug for major depression, appetite stimulation
SE: Weight gain, marked sedation

Mirtazapine

20

TCA
Inhibits neuronal reuptake of Dopamine
Drug for smoking cessation
SE: Weight loss, seizures, priapism
Lowers seizure threshold

Bupropion

21

MAOI
Inhibits monoamine oxidase type A and type B
Drug for Parkinsons
SE: Insomnia, Orthostatic hypotension
Hypertensive crisis when taken with Tyramine (sympathomimetic in cheese/wine)
Serotonin syndrome when taken with SSRIs

Phenelzine
(Tranylcypromine, Selegiline)

22

Sx of Serotonin Syndrome

FAT CHD (KID)
Fever
Agitation
Tremor
Clonus
Hyperreflexia
Diaphoresis

23

Precipitating drug for Malignant Hyperthermia

Succinylcholine

24

Onset/Pathophysio of Malignant Hyperthermia

Within Minutes
Massive Ca release from SR

25

First Line Tx for Malignant Hyperthermia

Dantrolene

26

Participating drug for Serotonin Syndrome
MMMSST

MAOI
Meperidine
MDMA
SSRIs
St. John's Wort
TCA

27

Onset/Pathophysio of Serotonin Syndrome

Within Hours
Excess Serotonin

28

First line Tx for Serotonin Syndrome

Sedation
Paralysis
Intubation
Ventilation

29

Precipitating drug for Neuroleptic Malignant Syndrome

Antipsychotics

30

Onset and Pathophysio of Neuroleptic Malignant Syndrome

1-3 days
Dopamine antagonism

31

First line Tx for Neuroleptic Malignant Syndrome

Diphenhydramine