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Flashcards in Antidepressants Jeopardy Deck (40)
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1
Q

The half-life of this SSRI is about one week.

A

Fluoxetine (Prozac)

2
Q

If an SSRI with a short half life is abruptly stopped, it may result in this.

A

Discontinuation Syndrome

3
Q

SSRI’s and MAOI’s used in combination carry a high risk of this side effect.

A

Serotonin syndrome

4
Q

This is the most likely SSRI to cause the side effect of weight gain.

A

Paroxetine (Paxil)

5
Q

The washout period when switching from an MAOI to any SSRI is this.

A

2 weeks

6
Q

These two SSRI’s have very short half lives and should be tapered to be discontinued.

A
  • Paroxetine (Paxil)

- Fluvoxamine (Luvox)

7
Q

Whether the dose is very high, moderate, or low, this NT’s reuptake is blocked by venlafaxine (Effexor).

A

Serotonin

8
Q

At very high doses (>375mg/d) of venlafaxine (Effexor), this NT’s reuptake may begin to be blocked.

A

Dopamine

9
Q

This SNRI is preferred for painful sx of depression or diabetic neuropathic pain.

A

Duloxetine (Cymbalta)

10
Q

As with the SSRI’s, some pts take SNRI’s for depression have an initial response, continue taking the medication, but then experience this.

A

Poop-out syndrome (relapse)

11
Q

As with the SSRI’s, some pts take SNRI’s for depression, have an initial response, continue taking the medication
but then experience this.

A

Induced bipolar state

12
Q

While venlafaxine (Effexor) may cause the side effect of sweating, ironically it may be helpful to perimenopausal women with this.

A

Hot flashes/flushes

13
Q

Venlafaxine (Effexor) has this relatively common, dose dependent, cardiac system related side effect.

A

Increased BP

14
Q

This medication is the most well known NDRI.

A

Buproprion (Wellbutrin)

15
Q

NDRI’s are useful in treating cravings from dependence on this substance.

A

Nicotine (smoking cessation)

16
Q

Not only do NDRI’s not have this common SSRI side effect, NDRI’s may be used to treat pts who have this SSRI side effect.

A

Sexual dysfunction

17
Q

Like most anti-depressants, at typical doses NDRI’s carry a small risk of this serious side effect, but the risk increases from 0.4% to 4% at very high doses.

A

Seizure

18
Q

Compared to SSRI’s or SNRI’s, NDRI’s are less effective in treating this class of psychiatric illnesses.

A

Anxiety disorders

19
Q

NDRI’s may be especially helpful in treating this sleep disturbance that is seen in atypical depression.

A

Hypersomnia (>10 hours/night)

20
Q

NDRI’s commonly do this to a pt’s weight.

A

Decrease (or no change)

21
Q

While not a first line treatment, NDRI’s “stimulating” effects may be helpful in treating children and adults with this disorder.

A

ADHD

22
Q

NDRI onset of therapeutic action is usually not immediate, but is delayed until this time period.

A

2-4 weeks

23
Q

NaSSA stands for this.

A

Noradrenergic and Specific Serotonergic Agent.

24
Q

NaSSA’s novel MoA by which norepinephrine and serotonin system activity is increased is this.

A

Pre-synaptic alpha-2 adrenergic antagonist

25
Q

The medication that is in the NaSSA class is this.

A

Mirtazepine (Remeron)

26
Q

SSRIs or venlafaxine (Effexor) may cause these common side effects which NaSSA’s 5HT-3 antagonism may help reduce or remove.

A

GI side effects (nausea, diarrhea, stomach cramps)

27
Q

This mirtazapine (remeron) side effect is more likely in F than M, before menopause than after, and is unlikely to be a problem if it has not occurred w/in the first 6 weeks of tx.

A

Weight gain

28
Q

Pts taking mirtazapine (Remeron) and an MAO-I at the same time, or within 2 weeks of the other, are at risk for this serious side effect.

A

Serotonin syndrome

29
Q

Mirtazapine (remeron) is an antagonist of: a presynaptic adrenergic alpha2-autoreceptors, serotonin post synaptic receptors, and this post synaptic receptor.:

A

Histamine (H1)

30
Q

Onset of therapeutic effect of mirtazapine on insomnia and anxiety is typically in this time period.

A

Almost immediately

31
Q

Cytochrome P450 enzyme system that is significantly effected by mirtazepine (Remeron) is?

A

None

32
Q

A tertiary amine, amitriptyline (Elavil), is metabolized to a secondary amine which is this TCA.

A

Nortriptyline (Pamelor)

33
Q

Blurred vision, urinary hesitancy, dry mouth, and constipation are due to this neurotransmitter receptor activity by TCA’s.

A

Anticholinergic activity

34
Q

A tertiary amine, imipramine (Tofranil), is metabolized to a secondary amine which is this TCA.

A

Desipramine (Norpramin)

35
Q

TCA’s may be more effective than SSRI’s in treating depression for this sex of the clinical population.

A

Men

36
Q

Fluoxetine (Prozac), paroxetine (Paxil), bupropion (Wellbutrin), duloxetine (Cymbalta) and other medications may increase all TCA’s concentration by inhibiting this p450 enzyme.

A

CYP450 2D6

37
Q

Side effects of dizziness, sedation, and hypotension likely result from TCA’s antagonist activity of this receptor,

A

Alpha-1 adrenergic receptor

38
Q

Side effects of sedation and weight gain from TCA’s are likely due to antagonist activity at this receptor.

A

Histamine (H1)

39
Q

TCA’s mechanism of action for treating depression is this.

A

Serotonin and norepinephrine reuptake inhibition

40
Q

The dangerous side effects from a TCA overdose are cardiac arrhythmias caused by
blockade of this.

A

Na+ channels