Antidysrhythmics IV unPines

Question 1

action of antidysrhythmic drugs

Answer 1

depress contractility, excitability and automaticity; block adrenergic (sympathetic) simulation; incrase repolarization (phase to move to refractory/rest phase)

Question 2

define action potential

Answer 2

when there is movement of Na and K across cell membrane that causes depolarization/contraction

Question 3

define refractory phase

Answer 3

resting state; phase 4 of action potential; cell CANNOT respond to new stimulus; K is inside and Na is outside once again

Question 4

define automaticity

Answer 4

electrical impulse formation

Question 5

define excitability or irritability

Answer 5

cell CAN respond to stimulus

Question 6

define depolarization

Answer 6

muscle activated; contraction starts; systole to eject blood; Na rushing inside and Ca joined in, while K moving outside; phase starts at 0

Question 7

define repolarization

Answer 7

movement towards refractory/resting phase; K is completely out now; phase starts at 1 and plateaus at phase 2 and continues to phase 3 of action potential

Question 8

the phase between repolarization and refractory phase?

Answer 8

phase 3; magnesium activates the Na-K pump to fascilitate the movement of K back into the cell; Na and Ca move out; when complete, refractory phase 4 has been reached.

Question 9

define refractory phase

Answer 9

resting state; diastole to fill in with blood; phase 4 of action potential; cell CANNOT respond to new stimulus; K is inside and Na is outside once again

Question 10

class IV Calcium Channel blockers do this

Answer 10

block movement of Calcium into cell (no conduction or contraction); decrease automaticity/elecrical formation; slow conduction and prolong refractory/rest period

Question 11

back it up! action of calcium channel blocker as antianginal

Answer 11

vasodilation of coronary and peripheral vessels to aleviate angina and decrease BP; decrease contractility/workload/O2 need

Question 12

2 examples of antidysrhythmic class IV calcium channel blockers

Answer 12

diltiazem and verapamil (don’t have “PINE” in it; but it’s still a calcium channel blocker)

Question 13

class IV calcium channel blockers indication

Answer 13

SUPRAVENTRICULAR TACHYCARDIA (HR 100-300 bpm) aka PSVT; dysrhythmia originate from foci above the bifurcation of Bundle of His (could be AV or SA node problem); A. Fib/Flutter; tachycardia on exertion

Question 14

class IV Calcium Channel blockers contraindication

Answer 14

DIGITALIS TOXICITY; caution with renal and hepatic impairment

Question 15

class IV calcium channel blocker route

Answer 15

IV; do NOT give verapamil with propanolol in same IV

Question 16

class IV calcium channel blocker drug interaction

Answer 16

simvastatin zocor d/t rhabdomyolysis potentiated

Question 17

calcium channel blocker food interaction

Answer 17

DON’T EAT GRAPEFRUIT; can make BP go up/down

Question 18

how to quit taking calcium channel blockers

Answer 18

taper off doses

Question 19

MD ordered BB and CCB. Pt BP is low, hold which?

Answer 19

hold the calcium channel blocker r/t action affecting VASODILATION

Question 20

monitor what with diltiazem

Answer 20

kidney funtion

Question 21

monitor what with verapamil

Answer 21

s/e BLE edema, constipation, dizziness, HA, hypotension

Question 22

monitor what s/e

Answer 22

dizziness, HA, constipation, kidney, liver