***Antiemetic meds only (no patho)*** Flashcards
(151 cards)
1
Q
What antiemetic can tx motion sickness? (3)
A
1) Anticholinergics
2) Dopamine 2 Antagonists
3) H1 Receptor Antagonists (antihistamines)
2
Q
what kind of med is Olanzapine (Zyprexa)?
A
antipsychotic
3
Q
what drug interacts with pimozide?
A
Aprepitant (Emend)
4
Q
which antiemetics can cause dizziness?
A
1) Haloperidol (Haldol)
5
Q
which meds cause suicide ideations? (2)
A
1) Metoclopramide (Reglan)
2) Olanzapine (Zyprexa)
6
Q
what antiemetic is indicated for schizophrenia? (2)
A
1) Haloperidol (Haldol)
2) Prochlorperazine (Compazine)
7
Q
what antiemetics cause fever?
A
5-HT3 (Serotonin) Antagonist
8
Q
what do anticholinergics block? where?
A
block acetylcholine at the muscarinic receptors
9
Q
what antiemetics cause diarrhea? (2)
A
1) 5-HT3 (Serotonin) Antagonist → Ondansetron (Zofran)
2) Neurokinin-1 antagonist (NK-1)
10
Q
what antiemetic can be used for severe vomiting?
A
phenothiazines
11
Q
what antiemetics are given for chemotherapy N/V? (2)
A
1) 5-HT3 (Serotonin) Antagonist
2) Dopamine 2 Antagonist
3) Corticosteroids
4) NK-1 antag
12
Q
which antiemetic is used for morning sickness? (2)
A
1) Prochlorperazine (Compazine)
2) H1 Receptor Antagonists (antihistamines)
13
Q
what antiemetics are given for radiation N/V?
A
1) 5-HT3 (Serotonin) Antagonist
14
Q
what antiemetics are given for post-op N/V? (3)
A
1) 5-HT3 (Serotonin) Antagonist
2) Dopamine 2 Antagonist
3) Phenothiazines (N/V r/t anesthesia)
15
Q
what antiemetics cause headache? (2)
A
1) 5-HT3 (Serotonin) Antagonist → Ondansetron (Zofran)
2) Neurokinin-1 antagonist (NK-1)
16
Q
which antiemetics are also used for allergies?
A
H1 Receptor Antagonists (antihistamines)
17
Q
what kind of antiemetic is Haloperidol (Haldol)?
A
Dopamine 2 receptor antagonist
18
Q
which meds are used for anticipatory N/V?
A
Anxiolytics/benzodiazepines
19
Q
what antiemetic cause dry mouth? (3)
A
1) Anticholinergics
2) H1 Receptor Antagonists (antihistamines)
3) Cannabinoids
20
Q
which antiemetic is used to control tics & vocal utterances of tourette’s disorder?
A
Haloperidol (Haldol)
21
Q
which antiemetic is used for non-psychotic anxiety?
A
Prochlorperazine (Compazine)
22
Q
which antiemetics are metabolized by liver and excreted in urine? (3)
A
1) 5-HT3 (Serotonin) Antagonist
2) Prochlorperazine (Compazine)
3) Aprepitant (Emend) urine & feces
23
Q
what antiemetic is a Butyrophenone derivative?
A
Haloperidol (Haldol)
24
Q
which antiemetic causes vertigo?
A
Cannabinoids
25
what drug interacts with warfarin?
Aprepitant (Emend)
26
what is the suffix for 5-HT3 (Serotonin) Antagonist drugs?
"setron"
27
what antiemetics cause urinary retention? (2)
1) Anticholinergics
2) H1 Receptor Antagonists (antihistamines)
28
which med is indicated for depressive episodes related to bipolar 1?
Olanzapine (Zyprexa)
29
what antiemetics cause blurred vision? (3)
1) Anticholinergics
2) Prochlorperazine (Compazine)
3) H1 Receptor Antagonists (antihistamines)
30
what kind of antiemetic is ondansetron (zofran) ?
5-HT3 (Serotonin) Antagonist
31
What kind of antiemetic is Trimethobenazamide (Tigan)?
Dopamine 2 Antagonist
32
what do H1 Receptor Antagonists (antihistamines) block?
muscarinic receptors
33
what type of antiemetic are phenothiazines?
dopamine 2 antagonists
34
what antiemetics cause exacerbation of narrow-angle glaucoma? (1)
1) anticholinergics
35
what antiemetics cause hypotension? (4)
1) 5-HT3 (Serotonin) Antagonist
2) Phenothiazines --> Prochlorperazine (Compazine)
3) H1 Receptor Antagonists (antihistamines)
4) Olanzapine (Zyprexa)
36
how must Ondansetron (Zofran) be taken in hepatic & renal impairment?
use lowest dose
37
what meds may cause anxiety?
corticosteroids
38
which antiemetic causes euphoria?
Cannabinoids --> Dronabinol (Marinol)
39
which med causes weight gain?
Olanzapine (Zyprexa)
40
What kind of antiemetic is Metoclopramide (Reglan)?
Dopamine 2 Receptor Antagonist
41
which med is indicated for tx of resistant depression?
Olanzapine (Zyprexa)
42
Which antiemetic is contraindicated in bowel obstruction?
Metoclopramide (Reglan)
43
What kind of antiemetic is Prochlorperazine (Compazine)?
Phenothiazine → dopamine 2 antagonist
44
what meds may cause acne?
corticosteroids
45
which meds are typically used as an adjunct agent for acute or delayed N/V?
Anxiolytics/benzodiazepines
46
what drug interacts with oral contraceptives?
Aprepitant (Emend)
47
What is Metoclopramide (Reglan) also classified as?
a non-phenothiazine
48
which antiemetic causes tachycardia?
Cannabinoids
49
what antiemetics cause skin irritation? (1)
1) anticholinergics
50
What antiemetics cause constipation? (2)
1) Ondansetron (Zofran)
2) Neurokinin-1 antagonist (NK-1)
51
what antiemetic is indicated for diabetic gastroparesis?
1) Metoclopramide (Reglan)
52
which med is indicated for acute agitation related to schizophrenia and bipolar 1 mania?
Olanzapine (Zyprexa)
53
what meds may cause hyperactivity?
corticosteroids
54
what antiemetics can cause tardive dyskinesia? (3)
1) Metoclopramide (Reglan)
2) Haloperidol (Haldol)
3) Prochlorperazine (Compazine)
55
which antiemetic causes hypo and hypertension?
H1 Receptor Antagonists (antihistamines)
56
which antiemetic causes photosensitivity?
phenothiazines
57
which med can cause gastritis?
Neurokinin-1 antagonist (NK-1)
58
which antiemetic causes photophobia?
Prochlorperazine (Compazine)
59
what antiemetic must be removed before an MRI?
anticholinergics
60
which antiemetic causes autonomic effects?
phenothiazines
61
which antiemetic causes mood changes?
Dronabinol (Marinol)
62
which antiemetics cause extrapyramidal sx (EPS)? (3)
1) Metoclopramide (Reglan)
2) Haloperidol (Haldol)
3) Prochlorperazine (Compazine)
63
which antiemetic is contraindicated in dementia?
Haloperidol (Haldol)
64
which antiemetics cause paranoid reactions?
Cannabinoids
65
what antiemetics cause sedation? (4)
1) Haloperidol (Haldol)
2) Cannabinoids
3) Olanzapine (Zyprexa)
4) Anxiolytics/benzodiazepines
66
What is the black box warning for Metoclopramide (Reglan)?
may cause tardive dyskinesia
67
what drug interacts with corticosteroids?
Aprepitant (Emend)
68
what kind of antiemetic is diphenhydramine?
H1 Receptor Antagonists (antihistamines)
69
what antiemetics cause QT prolongation? (2)
1) 5-HT3 (Serotonin) Antagonists
2) Haloperidol (Haldol)
70
which antiemetic can cause psychosis in extreme cases?
Dronabinol (Marinol)
71
what meds can cause agitation?
Anxiolytics/benzodiazepines
72
what drug causes dehydration?
Aprepitant (Emend)
73
what kind of medication is Dexamethasone (Decadron)?
corticosteroid
74
which antiemetic is an appetite stimulant?
Dronabinol (Marinol)
75
which antiemetics are contraindicated in those with severe hypo/hypertension?
Phenothiazines
76
which antiemetic is contraindicated in GI bleeding?
Metoclopramide (Reglan)
77
which antiemetic is cautioned in pts with a hx of alcohol or substance abuse?
Dronabinol (Marinol)
78
what kind of antiemetic is Scopolamine (Transderm Scop)?
anticholinergic
79
For which antiemetic might urine become pink to red-brown in color?
phenothiazines
80
which antiemetics causes restlessness?
1) Metoclopramide (Reglan)
81
what meds can cause dependence & withdrawl sx?
Anxiolytics/benzodiazepines
82
what kind of antiemetic is Promethazine (Pherergan)?
1) Dopamine 2 Antagonist
2) H1 Receptor Antagonists (antihistamines)
83
what meds can cause confusion?
Anxiolytics/benzodiazepines
84
which antiemetics are contraindicated in those with liver dysfunction?
phenothiazines
85
what does Ondansetron (Zofran) block? where?
Blocks Serotonin in the chemoreceptor trigger zone (CTZ)
86
what drug causes liver enzyme elevation?
Aprepitant (Emend)
87
which antiemetic causes endocrine effects?
phenothiazines
88
which antiemetic is contraindicated in epileptics?
Metoclopramide (Reglan)
89
which antiemetics can cause dystonia? (2)
1) Haloperidol (Haldol)
2) Prochlorperazine (Compazine)
90
which antiemetic can cause depression?
Dronabinol (Marinol)
91
which meds effect GABA neurotransmitter?
Anxiolytics/benzodiazepines
92
what kind of medication is prednisone (deltasone)?
corticosteroid
93
How can Ondansetron (Zofran) be dosed?
4 mg or 8 mg
94
Patients with severe toxic CNS depression or comatose states from any cause CANNOT take what antiemetic?
Haloperidol (Haldol)
95
Patients in comas or severe CNS suppression CANNOT take what anitemetic?
phenothiazines
96
what drug can cross the BBB?
Aprepitant (Emend)
97
which antiemetics are contraindicated in those with severe renal impairment?
phenothiazines
98
which antiemetic should be used with caution in pts with underlying psych disorders (mania, depression, schizophrenia) ?
Dronabinol (Marinol)
99
what meds are used to prevent and treat acute and delayed nausea associated with highly emetogenic chemotherapy?
Neurokinin-1 antagonist (NK-1)
100
what other properties do Dopamine 2 Antagonists have?
antihistamine & anti-cholinergic properties
101
which antiemetic is contraindicated in pheochromocytoma?
Metoclopramide (Reglan)
102
what kind of antiemetic is meclizine?
H1 Receptor Antagonists (antihistamines)
103
who is Ondansetron (Zofran) contraindicated in?
patients taking anticonvulsants
104
what antiemetics cause fatigue? (2)
1) Ondansetron (Zofran)
2) Neurokinin-1 antagonist (NK-1)
105
which meds can cause hallucinations?
Anxiolytics/benzodiazepines
106
which antiemetics cause decreased CNS stimulation?
phenothiazines
107
what kind of antiemetic is doxylamine succinate?
H1 Receptor Antagonists (antihistamines)
108
what meds are CNS depressants that interfere with afferent nerves?
Anxiolytics/benzodiazepines
109
Which antiemetics causes drowsiness? (4)
1) Metoclopramide (Reglan)
2) Prochlorperazine (Compazine)
3) H1 Receptor Antagonists (antihistamines)
4) Anxiolytics/benzodiazepines
110
what meds may cause insomnia? (2)
1) Corticosteroids
2) Dronabinol (Marinol)
111
which antiemetic is contraindicated in parkinsons?
Haloperidol (Haldol)
112
what Anxiolytics/benzodiazepines are used as an antiemetic? (2)
1) Alprazolam (Xanax)
2) Lorazepam (Ativan)
113
which antiemetic is indicated for anorexia?
Dronabinol (Marinol)
114
what med can cause anorexia?
Neurokinin-1 antagonist (NK-1)
115
What are the 3 subtypes of Dopamine 2 Antagonists?
1) Piperaze phenothiazine/ antipsychotics → prochlorperazine
2) Metoclopramide (Reglan)
3) Butyrophenone derivative/Antipsychotic → Droperidol and Haloperidol (Haldol)
116
What antiemetics are considered second-line therapy?
Dopamine 2 Antagonists
117
which antiemetics cause cardiac arrhythmias?
phenothiazines
118
which antiemetic is highly protein bound?
Dronabinol (Marinol)
119
What antiemetic is indicated for GERD? (1)
1) Metoclopramide (Reglan)
120
how can alprazolam (xanax) be given and what is the dose?
given PO --> 0.5 to 2 mg
121
which antiemetic causes neuroleptic malignant syndrome? (3)
1) Metoclopramide (Reglan)
2) Prochlorperazine (Compazine)
3) Olanzapine (Zyprexa)
122
what meds inhibit substance P?
Neurokinin-1 antagonist (NK-1)
123
which meds have a blackbox warning for Elderly Patients with Dementia-Related Psychosis? (2)
1) Haloperidol (Haldol)
2) Olanzapine (Zyprexa)
124
what antiemetic can be used for intractable hiccups?
phenothiazines
125
what drug can cause hiccups?
Aprepitant (Emend)
126
which antiemetic adjuvant meds are anti-inflammatory?
corticosteroids
127
which antiemetic is contraindicated in patients taking antipsychotic drugs?
Prochlorperazine (Compazine)
128
what kind of med is Drobabinol (Marinol) ?
Cannabinoids
129
which antiemetics are contraindicated in children?
Prochlorperazine (Compazine)
130
what properties do H1 Receptor Antagonists (antihistamines) have?
anticholinergic properties
131
which antiemetic is cautioned in elderly pts due to an increased risk of neuro-psychoactive effects?
Dronabinol (Marinol)
132
which class of meds are used as adjuvant therapy but have a low degree of evidence for tx of N/V?
what are they indicated for?
corticosteroids
CINV
133
which med is contraindicated in combination with fluoxetine?
Olanzapine (Zyprexa)
134
what kind of med is aprepitant (emend)?
Neurokinin-1 antagonist (NK-1)
135
the precise mechanism of action of corticosteroids for N/V is unknown, but what do they do that may inhibit N/V?
Suppresses prostaglandin release from hypothalamus
136
how can lorazepam (Ativan) be given and what is the dose?
PO, SL, or IV --> 0.5 to 2 mg
137
how should corticosteroids be administered?
slowly
138
what are the two type of cannabinoid receptors?
1) CB-1 receptors: GI tract
2) CB-2 receptors: inflammatory and epithelial cells
139
which med is contraindicated in combo with lithium?
Olanzapine (Zyprexa)
140
Cannabinoids are equal in efficacy to what?
ondansetron
141
which antiemetic is indicated for CINV that has failed standard tx?
Dronabinol (Marinol)
142
what drug can cause steven johnson syndrome?
Aprepitant (Emend)
143
how can Dronabinol (Marinol) be dosed?
2.5 mg
5 mg
10 mg
144
what labs should be monitored with Olanzapine (Zyprexa)? (3)
CBC
Glucose
Lipid Profile
145
which med is contraindicated in combo with valproate?
Olanzapine (Zyprexa)
146
which meds are given in combo with other antiemetics?
Neurokinin-1 antagonist (NK-1)
147
Neurokinin-1 antagonists are inducers of what?
the CYP 450 system
148
what is the route and dosage of Aprepitant (Emend)?
150 mg IV
149
Routes:
1) Ondansetron (Zofran)?
2) Metoclopramide (Reglan)?
3) Haloperidol (Haldol)?
4) Phenothiazines?
5) Dronabinol (Marinol)?
6) Olanzapine (Zyprexa)?
7) Alprazolam (Xanax)?
8) Lorazepam (Ativan)
9) Neurokinin-1 antagonist (NK-1)?
10) Aprepitant (Emend)?
1) PO, SL, IV, IM
2) PO, IV, IM
3) PO, IV, IM
4) PO, IV, IM, Suppositories
5) PO
6) PO, IM
7) PO
8) PO, SL, IV
9) PO, IV
10) IV
150
which meds are pregnancy category B? (2)
1) Ondansetron (Zofran)
2) Metoclopramide (Reglan)
151
which meds are pregnancy category C? (3)
1) Haloperidol (Haldol)
2) Dronabinol (Marinol)
3) Olanzapine (Zyprexa)
