antifug

Question 1

What is the brand name for Fluconazole?

Answer 1

Diflucan

Question 2

What drug class is Fluconazole in?

Answer 2

Imidazole Antifungal

Question 3

What are the indications for Fluconazole?

Answer 3

Candidal vulvovaginitis (Uncomplicated, Complicated), Candidiasis, Cryptococcal meningitis, Oropharyngeal candidiasis

Question 4

What is the mechanism of action of Fluconazole?

Answer 4

Inhibits (CYP51) biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane and
altering its permeability

Question 5

What are the black box warnings for Fluconazole?

Answer 5

None

Question 5

What are the major contraindications for Fluconazole?

Answer 5

Hypersensitivity, Concurrent ergot alkaloids, CYP3A4/5 substrates that prolong QTc

Question 6

What are the common adverse drug reactions for Fluconazole?

Answer 6

Headache

Question 7

What are the rare but serious adverse drug reactions for Fluconazole?

Answer 7

Stevens-Johnson syndrome, Arrhythmias (prolonged QTc interval), Adrenal suppression, Agranulocytosis, Seizures, Elevated LFTs, Hypokalemia

Question 8

What are the key counseling points for Fluconazole?

Answer 8

Many medications, including OTC medications, interact with fluconazole. Do not take any new medications without consulting your doctor or pharmacist. If taking a weekly dose, take on same day and time each week.

Question 9

What is the brand name of Ketoconazole?

Answer 9

Nizoral

Question 9

What are the indications for Ketoconazole?

Answer 9

Candidiasis, Dandruff, Pityriasis
versicolor, Seborrheic dermatitis, Tinea (corporis, cruris, pedis)

Question 9

What drug class is Ketoconazole in?

Answer 9

Imidazole Antifungal

Question 10

What is the mechanism of action of Ketoconazole?

Answer 10

Inhibits (CYP51) biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane and altering its permeability.

Question 11

What are the major contraindications for Ketoconazole?

Answer 11

Hypersensitivity

Question 12

What are the black box warnings for Ketoconazole?

Answer 12

None

Question 13

What are the rare but serious adverse drug reactions for Ketoconazole?

Answer 13

Rash, Hair loss

Question 13

What are the common adverse drug reactions for Ketoconazole?

Answer 13

Application site rxn with foam

Question 14

What are the key counseling points for Ketoconazole?

Answer 14

Apply thin layer to affected area of skin. Skin should be intact. Do not get in your eyes, nose, mouth, or vagina. Do not wash the areas where you applied this medicine for at least 3 h after application. Cosmetics (makeup or sunscreens) may be put on the affected areas
for 20 mins after application. Topical products are alcohol based and flammable immediately after application.

Question 15

Are Azoles safe to use during pregnancy?

Answer 15

No - High risk in first trimester =
Category D

Question 16

What is the brand name for Nystatin Systemic?

Answer 16

Bio-Statin

Question 17

What drug class is Nystatin Systemic in?

Answer 17

Polyene Antifungal

Question 18

What are the indications for Nystatin Systemic?

Answer 18

GI candidiasis (nonesophageal) and Oropharyngeal candidiasis

Question 19

What is the mechanism of action of Nystatin Systemic?

Answer 19

Binds to the sterols in fungal cell walls, damaging the fungal cell wall membrane and altering its permeability for leakage of cellular contents.

Question 20

What are the major contraindications for Nystatin Systemic?

Answer 20

Hypersensitivity

Question 21

What are the black box warnings for Nystatin Systemic?

Answer 21

None

Question 22

What are the common adverse drug reactions for Nystatin Systemic?

Answer 22

None known, 1-10% : GI distress, Nausea, Vomiting, Constipation, Oral irritation

Question 23

What are the rare but serious adverse drug reactions for Nystatin Systemic?

Answer 23

Rash

Question 24

What are the key counseling points for Nystatin Systemic?

Answer 24

Store the tablets at room temperature. Shake suspension well before using.

Question 25

What is the brand name for Nystatin Topical?

Answer 25

Mycostatin

Question 26

What drug class is Nystatin Topical in?

Answer 26

Polyene Antifungal

Question 27

What are the indications for Nystatin Topical?

Answer 27

Candidiasis of skin

Question 28

What is the mechanism of action of Nystatin Topical?

Answer 28

Binds to the sterols in fungal cell walls, damaging the fungal cell wall membrane and altering its permeability allowing for leakage of cellular contents.

Question 29

What are the major contraindications for Nystatin Topical?

Answer 29

Hypersensitivity

Question 30

What are the black box warnings for Nystatin Topical?

Answer 30

None

Question 31

What are the common adverse drug reactions for Nystatin?

Answer 31

None known, 1-10% : Dry skin, Skin irritation

Question 32

What are the rare but serious adverse drug reactions for Nystatin?

Answer 32

Rash, Hypersensitivity reactions, Stevens-Johnson Syndrome

Question 33

What are the key counseling points for Nystatin?

Answer 33

Apply to the affected area of skin. Skin should be intact. Do not get it in eyes, nose, or mouth. Avoid occlusive dressings, tight-fitting diapers, and plastic pants if using on diaper area of children.

Question 34

What is the brand name for Terbinafine?

Answer 34

Lamisil

Question 35

What drug class is Terbinafine in?

Answer 35

Allylamine Antifungal

Question 36

What are the indications for Terbinafine?

Answer 36

Activity against dermatophytes, Yeasts (e.g., candida), and Dimorphic fungi

Question 37

What is the mechanism of action of Terbinafine?

Answer 37

Allylamine that inhibits ergosterol synthesis through inhibition of squalene epoxidase to destabilize the fungal cell membrane

Question 38

What are the major contraindications for Terbinafine?

Answer 38

Hypersensitivity, Existing liver disease

Question 39

What are the common adverse drug reactions for Terbinafine?

Answer 39

Local irritation for topical

Question 40

What are the rare but serious adverse drug reactions for Terbinafine?

Answer 40

Hepatotoxicity with systemic, Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

Question 41

What are the key counseling points for Terbinafine?

Answer 41

Possible temporary alterations to taste and smell - can be taken with or without food/water.