Antifungal

Question 0

Trichopyton

Answer 0

Infect skin nail & hair

Trichopyton rubrum

Question 1

Epidermophyton

Answer 1

Infect skin & nails

Epidermophyton floccosum

Question 2

Microsporum

Answer 2

Affect hair and skin

Classified by habitat

Question 3

Tinea pedis

Answer 3

T. Interdigitale (t.mentagrophytes complex)

Question 4

Erythrasma

Answer 4

Gram positive bacterial infection
- corynebacterium minutissmum

Improve foot hygiene, topical fusion acdinor clindamycin lotion

Will show up pink under woods light

Question 5

Pure tic slow spreading brown scale and maceration

Answer 5

Erythrasma

Question 6

What is te only type of onychomycosis to affect the dorsal aspect of the nail plate

Answer 6

Superficial white onychomycosis

Usually a result of t.mentagrophytes

Question 7

Cause of proximal white onychomycosis

Answer 7

Most commonly caused by trichophyton rubrum

Question 8

Unicellular round or oval fungal mycosis

Answer 8

True yeasts
Malassezia fur fur
Cryptococcus neoformans

Question 9

Long non-branching stands of fungal infection

Answer 9

Candidia spp.

Question 10

Long branching filaments of fungi that intertwine forming mycelium causing mycosis

Answer 10

Moulds

Question 11

Trichophyton is classified as a

Answer 11

Dermatophyte

Question 12

Dermatophytes digest

Answer 12

Keratin in hair, skin & nails

Question 13

Amorolfine is the active ingredient in

Answer 13

Loceryl 5% paint

Question 14

Nystatin (topical)

Answer 14

Mycostatin

Question 15

Terbinafine is the active ingredient in

Answer 15

Lamisil 1%

Lamisil tablets in specific circumstances

Question 16

Griseofulvin is the active ingredient in

Answer 16

Grisovin

Oral in specified circumstances

Question 17

Broad spectrum antifungals

Answer 17

Azoles

Question 18

Narrow spectrum of antifungal

Answer 18

Griseofulvin

Question 19

Cell wall synthesis inhibiting antifungals

Answer 19

Azoles
Allylamines
Amorolfine
Echinocandins

Question 20

Predominant component of fungal cell wall

Answer 20

Ergosterol

Question 21

Antifungals that interfere with cell wall function

Answer 21

Amphotericin

Nystatin

Question 22

DNA synthesis inhibiting antifungals

Answer 22

Pyrimides - flucytosine

Benzofurines - griseofulvin

Question 23

Miconazole is available as a tincture for use on nails what drug class is it and what is the MOA & brand names

Answer 23

Daktarin, Resolve
Azoles - imidazoles
Inhibit enzyme, impairing synthesis of ergosterol in cell wall

Question 24

Imidazoles

Answer 24

All administered topically for 2-4 weeks - Miconazole - clotrimozole - econazole - bifonazole - ketoconazole

Question 25

Triazoles

Answer 25

All given orally - Fluconazole - Itraconazole - Voriconazole - Posaconazole (v serious cases)

Question 26

Canestan oral once-daily, mycospor

Answer 26

Bifonazole (cream1%) Azoles - imidazole Inhibit cell wall synthesis

Question 27

Canesten, clonea

Answer 27

Clotrimozole (cream & lotion 1%) Azoles - imidazole Inhibit cell wall synthesis

Question 28

Pevaryl

Answer 28

Econazole (cream 1%) Azoles - imidazole Inhibit cell wall synthesis

Question 29

Nizoral cream | Daktagold

Answer 29

Ketoconazole (cream 1%) Azoles - imidazole Inhibit cell wall synthesis

Question 30

Fluconazole interacts with

Answer 30

Warfarin - increase INR Anti- arrhytmics (amidarone) increase QT interval Macrolides

Question 31

What Azoles would you use in a severe systemic fungal infection

Answer 31

Voriconazole | Posaconazole

Question 32

In pregnancy the safe Azoles are

Answer 32

Clotrimozole Miconazole And econazole

Question 33

Allylamines

Answer 33

Terbinafine - Lamisil Inhibit an enzyme (squalene epoxidase) preventing ergosterol synthesis Fungicidal against dermatophytes Fungistatic against Candida albicans

Question 34

Terbinafine interactions

Answer 34

Venlafaxine Triglyclic antidepressants Rifampicin

Question 35

Do not use Lamisil for

Answer 35

Longer than 4weeks | Moccasin/plantar type tinea pedis

Question 36

Loceryl

Answer 36

Amorolfine targets 2 enzyme points in synthesis of ergosterol which compromises cell wall Broad coverage for dermatophytes and candida spp (high affinity for keratin)

Question 37

Bifonazole

Answer 37

Urea ointment - softens nail | Bifonazole cream