Blood Haemostasis & Coagulation Flashcards
0
Q
Vitamin k antagonists
A
Warfarin
(Coumadin, Marevan)
Phenindione
(Dindevan)
1
Q
Vitamin K action
A
Used in bleeding disorders
Is a necessary cofactor in synthesis of factor II, VII, IX, X & protein C & S
2
Q
Warfarin MOA
A
Inhibit enzymatic synthesis of vitamin K dependant clotting factors & anti thrombotic factors protein C & S
3
Q
Warfarin adverse reactions
A
Many foods ie garlic Amiodarone Apsrin & NSAIDs Azoles Macrolides Ciprofloxacin Metronidazole Fibrates Simvastin SSRIs Tampxifen Thyroid hormones Phenobarbital Carabamezepine At johns wort
4
Q
Heparin
A
Anti coagulant
Inactivate thrombin IIa & clotting factor Xa by binding to antithrombin III
