Antifungal and Antiviral

Question 0

Inhibits thymidilate synthase

Answer 0

Flucytosine

Question 1

Binds to ergosterol in fungal cell membranes

Answer 1

Amphotericin B

Question 2

Treatment for madura foot

Answer 2

Flucytosine

Question 3

MOA of azole family

Answer 3

Inhibit fungal P-450 dependent enzymes blocking ergosterol synthesis

Question 4

Treatment for candidiasis

Answer 4

Fluconazole

Question 5

Common adverse effects of azoles

Answer 5

GI disturbance (vomiting, diarrhea), rash and hepatotoxicity

Question 6

Inhibits beta-glucan synthase decreasing cell wall synthesis

Answer 6

Caspofungin

Question 7

Treatment of dermatophytosis

Answer 7

Griseofulvin

Question 8

Which of the following systemic antifungal is contraindicated to porphyria?

A. Griseofulvin
B. Terbinafine
C. Nystatin
D. Clotrimazole

Answer 8

A. Griseofulvin

Question 9

Squalene oxidase inhibitor

Answer 9

Terbinafine

Question 10

Antifungal that causes severe nephrotoxicity

Answer 10

Nystatin

Question 11

Anti-herpes that is activated by viral thymidine kinase to inhibit viral DNA polymerase

Answer 11

Acyclovir

Question 12

Inhibits viral DNA polymerase, causing chain termination

Answer 12

Anti-CMV

Question 13

Most common cause of blindness in AIDS

Answer 13

CMV retinitis

Question 14

Inhibits viral RNA polymerase, DNA polymerase, and HIV reverse transcriptase

Answer 14

Foscarnet

Question 15

Inhibit HIV reverse transcriptase after phosphorylation

Answer 15

Nucleoside reverse transcriptase (NRTI)

Question 16

Examples of NRTI

Answer 16

Abacavir
Didanosine
Lamivudine
Zidovudine
Tenofovir
Stavudine

Question 17

Inhibits HIV reverse transcriptase without requiring phosphorylation

Answer 17

Non-Nuvleoside Reverse Transcriptase Inhibitor (NNRTI)

Question 18

Examples of NNRTI

Answer 18

Delavirdine
Efavirenz
Etravirine
Nevirapine

Question 19

Anti HIV drug class given for prevention of maternal-fetal HIV transmission

Answer 19

NRTI

Question 20

Inhibit viral protein processing

Answer 20

Protease inhibitors

Question 21

Examples of protease inhibitors

Answer 21

All that ends with -navir

Question 22

Binds to gp41 subunit of viral envelope glycoprotein preventing fusion of viral and cellular membranes

Answer 22

Enfuvirtide (Fusion Inhibitor)

Question 23

Blocks viral attachment via transmembrane chemokine receptor CCR5

Answer 23

Maraviroc (CCR5 receptor antagonist)

Question 24

Inhibit early step replication and prevent uncoating by binding to M2 proton channels

Answer 24

Amantadine

Question 25

Uses of amantadine

Answer 25

Influenza A and rubella

Question 26

Inhibits neuraminidase

Answer 26

Oseltamivir and Zanamivir

Question 27

Drug of choice for influenza, including H1N1

Answer 27

Oseltamivir

Question 28

Degrades viral RNA via activation of host cell RNAase (ribonuclease)

Answer 28

Interferon-alpha

Question 29

Inhibits HBV DNA polymerase

Answer 29

Lamivudine

Question 30

Inhibits guanosine triphosphate formation

Answer 30

Ribavirin

Question 31

Contraindications to interferon-alpha

Answer 31

Pregnancy Autoimmune disease Cardiac arrhythmias