Antifungals

Question 1

Name the drug whose mechanism of action is described below:

Blocks ergosterol (unique to fungi) synthesis by inhibiting P-450

Answer 1

Azole family (ketoconazole, fluconazole, miconazole, voriconazole, and posaconazole)

Question 2

Name the drug whose mechanism of action is described below:

Binds ergosterol → produces membrane pores

Answer 2

Amphotericin B and nystatin

Question 3

Name the drug whose mechanism of action is described below:

Blocks ergosterol synthesis by blocking squalene epoxidase

Answer 3

Terbinafine

Question 4

Name the drug whose mechanism of action is described below:

Interferes with microtubule formation → inhibits mitosis

Answer 4

Griseofulvin

Question 5

Name the drug whose mechanism of action is described below:

Converted to 5-fluorouracil (5-FU) → blocks formation of purines

Answer 5

Flucytosine

Question 6

Name the antifungal drug(s) associated with each of the following unique toxicities:

Rigors, acute febrile reaction, nephrotoxicity, and arrythmias

Answer 6

Amphotericin B—follow BUN/creatinine daily. Note: newer lipid formulations (ie, AmBisome less nephrotoxic)

Question 7

Name the antifungal drug(s) associated with each of the following unique toxicities:

Photosensitivity, mental confusion, bone marrow suppression, and induces P-450

Answer 7

Griseofulvin

Question 8

Name the antifungal drug(s) associated with each of the following unique toxicities:

Antiandrogenic effects, adrenal suppression, and liver dysfunction

Answer 8

Azole family (especially ketoconazole)

Question 9

Name the antifungal drug(s) associated with each of the following unique toxicities:

Bone marrow suppression and alopecia

Answer 9

Flucytosine