antifungals Flashcards
antifungals for invasive
tericin, tin –> polyene
conazole –> triazoles
fungin –> echinocandin
cytosine –> fluoropyrimidine
antifungals for superficial
ketoconazole + azole –> imidazoles
nystatin –> polyene
fungerp –> triterpenoid
tericin, tin fungi-
fungicidal
tericin, tin MOA
binds ergosterol –> cell lysis via pores
tericin, tin indications
cryptococcal meningitis, candida endocarditis, mucormysis, aspergillus
tericin, tin ADEs
nephrotoxicity**, infusion rxn, electrolyte abnormalities
conazole fungi-
fungistatic
conazole MOA
ergosterol synthesis inhibitor
conazole indications
fluconazole –> candidiasis, prophylaxis
voriconazole –> aspergillosis
posaconazole –> prophylaxis
isavuconazole –> mucormycosis
conazole ADEs
–QTc prolongation** (except isavu)
–visual changes, photosensitivity (vori)
conazole DDI
CYP450
conazole narrowest + broadest spectrum
narrowest –> fluconazole
broadest –> posaconazole + isavuconazole
fungin fungi-
fungicidal –> candida
fungistatic –> molds
fungin MOA
glucan synthesis inhibitor
fungin indications
candidiasis, aspergillus
fungin ADEs
well-tolerated
cytosine MOA
inhibits protein, DNA, RNA, synthesis
cytosine indications
candida, cryptococcus
cytosine ADEs
bone marrow suppression**, hepatotoxicity, GI (from metabolism to fluorouracil)
cytosine warnings
avoid monotherapy
ketoconazole + azole fungi-
fungistatic
ketoconazole + azole MOA
ergosterol synthesis inhibitor
ketoconazole + azole indications
dermatophytes, mucocutaneous candida**
nystatin MOA
binds ergosterol –> cell lysis via pores
