Antigen Presentation

Question 1

Are MHC/HLA molecules polygenic or polymorphic

Answer 1

Both and have codominant expression

Question 2

B2 Microglobulin is necessary for stability of

Answer 2

MHC class I molecule

Question 3

What do MHC I antigens process

Answer 3

Endogenousd

Question 4

What are the source of peptides for MHC I

Answer 4

Proteasomes, TAP, peptide loading complex

Question 5

What is the primary source of class II MHC

Answer 5

Exogenous

Question 6

What is the effect of IFN gamma on MHC II

Answer 6

Unregulates transcription

Question 7

If you don’t hav TAP, what immmune system may be missing

Answer 7

Class I, CD8

Question 8

Which class uses invariant chain to provide stability

Answer 8

Class II

Question 9

A region of DNA taht encodes a group of molecules that recognize an antigen

Answer 9

MHC

Question 10

Class II has ___ transmembrane domains

Answer 10

2

Question 11

what is necessary for T cell killing

Answer 11

specific peptide and slef MHC

Question 12

DC secrete what to stimulate Th1

Answer 12

IL-12

Question 13

MHC-II fights _______ pathogens

Answer 13

extracelluar

Question 14

what blocks peptide binding groove in the production of MHC-II

Answer 14

invariant chain

Question 15

where is MHC-I expressed

Answer 15

any nucleated cell

Question 16

how do peptides enter the ER in MHC-I

Answer 16

TAP transporter

Question 17

How does MHC I and II break down foreign material

Answer 17

MHC-1: proteasome

MHC-II: lysosome

Question 18

where does DC react with Th

Answer 18

paracortex

Question 19

where are B cells found in lymph nodes

Answer 19

cortex (follicles)

Question 20

what is signal 1

Answer 20

when a TCR and MHC match

Question 21

what is signal 2?

Answer 21

When Co stim match (Cd80 or CD86)

Question 22

what are the encapsulated bacteria

Answer 22

streptococcal, meningococcal, and Hib

Question 23

Fc portion is part of which chainm

Answer 23

heavy

Question 24

what is involved in passive immunization

Answer 24

IgG

Question 25

what antibody is involved in secretions

Answer 25

IgA

Question 26

which IgG actrivate complement

Answer 26

1 and 3

Question 27

which IgG is inhibitory

Answer 27

4

Question 28

which antibody is most common for deficiency

Answer 28

IgA

Question 29

which antibody can cross the placenta

Answer 29

IgG

Question 30

what does IFN-gamma do MHC I? II?

Answer 30

make proteolytic degradation occur faster; increase lysosomes activity