Antigen Recognition and Activation of the Adaptive Immune System I

Question 1

Explain the role of lymph nodes and spleen in capture of epithelium and connective tissue antigens and blood-borne antigens, respectively.

Answer 1

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Question 2

Describe antigen presentation and the process by which dendritic cells capture antigen and become effective antigen-presenting cells (APCs).

Answer 2

x

Question 3

Explain the recognition of peptide-MHC complexes by T cell receptors (TCR) and the concept of MHC restriction.

Answer 3

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Question 4

Describe key properties of human class I and class II MHC genes and proteins (human leukocyte antigen, HLAs), 
      including polymorphic MHC genes, MHC-expressing cell types, MHC protein structure, 
      peptide binding to MHC proteins, MHC-TCR interactions and MHC-CD4/CD8 interactions.

Answer 4

x

Question 5

Compare and contrast the class I MHC pathway and class II MHC pathway for processing and presentation of cytosolic and extracellular proteins, respectively.

Answer 5

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Question 6

Explain how segregation of the class I MHC and class II MHC pathways of antigen processing enables the adaptive immune system to respond differently to extracellular and intracellular pathogens.

Answer 6

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