Antihistamines and Antileukotrienes Flashcards Preview

[OS 216] Immuno Exam 2 Carlos Cluster > Antihistamines and Antileukotrienes > Flashcards

Flashcards in Antihistamines and Antileukotrienes Deck (25)
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1

What is the one airway, one disease concept?

Allergic Rhinitis and Asthma are seemingly separate disorders but are actually manifestations of the same disease expressed to a greater or lesser extent

2

Time for peak in symptoms in Allergic rhinitis (AR)

1 hour after provocation

3

When do symptoms of AR and AS usually resolve?

12-24 hours

4

Predominant mediator types: early phase

Cysteinyl leukotrienes, Histamine

5

Predominant mediator types: late phase

Cysteinyl leukotrienes, Cytokines

6

two important pathways of inflammation in asthma

Cysteinyl leukotrienes and steroid-sensitive mediators

7

Three actions of Cysteinyl Leukotrienes

1. activation and recruitment of inflammatory cells 2. increased vascular permeability leading to edema 3. increased mucus secretion

8

Triple responses of Lewis

Wheal, flare, flush

9

MOA of H1 antihistamines

do not antagonize the binding of histamine; bind to different sites on the receptor to produce the opposite effect

10

All of the available H1 receptor antagonists are (reversible/irreversible), (competitive, non-competitive)

reversible, competitive

11

What H1 blocker has anti-parkinsonism effects?

Diphenhydramine

12

What h1 blocker has alpha-receptor blocking effects?

promethazine

13

What H1 blocker has Serotonin-blocking actions?

Cyproheptadine

14

Most 2nd gen and some 1st gen last for _____ hours.

24

15

Elimination of antihistamines

Renal

16

antihistamines have significant cardiac toxicity when taken in combination with:

ketoconazole, itraconazole, erythromycin, grapefruit

17

MOA of zileuton

Inhibitors of leukotriene synthesis: inhibition of 5 -lipoxygenase

18

MOA of monteleukast

Inhibitors of leukotriene (LTD4) binding

19

What is the Churg-Strauss syndrome?

systemic vasculitis accompanied by worsening asthma, pulmonary infiltrates and eosinophilia

20

T or F. Antileukotrienes are less effective than intranasal corticosteroids

T

21

Example of 1st gen Ethanolamines

diphenhydramine, dimenhydrinate

22

Example of 1st gen Alkylamines

chlorphenamine

23

Example of 1st gen Ethylenediamines

pyrilamine

24

Example of 1st gen Piperazines

hydroxyzine

25

Example of 1st gen Phenothiazines

promethazine