Flashcards in Antihistamines and Antileukotrienes Deck (25)
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1
What is the one airway, one disease concept?
Allergic Rhinitis and Asthma are seemingly separate disorders but are actually manifestations of the same disease expressed to a greater or lesser extent
2
Time for peak in symptoms in Allergic rhinitis (AR)
1 hour after provocation
3
When do symptoms of AR and AS usually resolve?
12-24 hours
4
Predominant mediator types: early phase
Cysteinyl leukotrienes, Histamine
5
Predominant mediator types: late phase
Cysteinyl leukotrienes, Cytokines
6
two important pathways of inflammation in asthma
Cysteinyl leukotrienes and steroid-sensitive mediators
7
Three actions of Cysteinyl Leukotrienes
1. activation and recruitment of inflammatory cells 2. increased vascular permeability leading to edema 3. increased mucus secretion
8
Triple responses of Lewis
Wheal, flare, flush
9
MOA of H1 antihistamines
do not antagonize the binding of histamine; bind to different sites on the receptor to produce the opposite effect
10
All of the available H1 receptor antagonists are (reversible/irreversible), (competitive, non-competitive)
reversible, competitive
11
What H1 blocker has anti-parkinsonism effects?
Diphenhydramine
12
What h1 blocker has alpha-receptor blocking effects?
promethazine
13
What H1 blocker has Serotonin-blocking actions?
Cyproheptadine
14
Most 2nd gen and some 1st gen last for _____ hours.
24
15
Elimination of antihistamines
Renal
16
antihistamines have significant cardiac toxicity when taken in combination with:
ketoconazole, itraconazole, erythromycin, grapefruit
17
MOA of zileuton
Inhibitors of leukotriene synthesis: inhibition of 5 -lipoxygenase
18
MOA of monteleukast
Inhibitors of leukotriene (LTD4) binding
19
What is the Churg-Strauss syndrome?
systemic vasculitis accompanied by worsening asthma, pulmonary infiltrates and eosinophilia
20
T or F. Antileukotrienes are less effective than intranasal corticosteroids
T
21
Example of 1st gen Ethanolamines
diphenhydramine, dimenhydrinate
22
Example of 1st gen Alkylamines
chlorphenamine
23
Example of 1st gen Ethylenediamines
pyrilamine
24
Example of 1st gen Piperazines
hydroxyzine
25
