ANTIHYPERTENSIVE-Sympathoplegics Flashcards
(25 cards)
Sympatholytics
Adrenergic antagonist
Adrenergic blockers
Sympathoplegics
What are the classification of sympathoplegics
Centrally acting sympathoplegics
Peripherally acting
Site of action ni centrally acting sympathoplegics
Vasomotor center
What agonist is centrally acting sympathoplegics
Alpha 2 agonist
Drugs in centrally acting
Clonidine
Methyldopa
Guanfacine
Guanabenz
Clonidine
(Catapress)
What is the S/E
Rebound HTN
-secondary to clonidine withdrawal
What is the remedy in S/E of clonidine
Reinstitute clonidine
Give Beta blocker
If hypertensive crisis
– sodium nitroprusside
S/E of methyldopa
Hepatotoxicity
Can lead to hemolytic anemia
( + coombs test)
Pro drug
Metabolized into active form in the CNS
Methyldopa
Aldomet
Types of peripherally acting
Adrenergic neuronal blockers
Ganglionic blockers
Alpha blocker
Beta blocker
Drugs in adrenergic neuronal blocker
Reserpine
Guanethide, guanadrel, bretylium
S/E of reserpine
Depression
SE If guanethide, guanadrel
Orthostatic hypotension
It inhibit vesicular uptake of dopamine
Reserpine
Inhibut release NE
Guanethide guanadrel
Drugs in ganglionic blocker
Hexamethonium
Trimethaphan
Mecamyline
Inhibit nicotinic receptor
Ganglionic blocker
Types of alpha blocker
Non selective
Selective alpha1 blockers
It binds to alpha1 and alpha2 blocking their action, give the drugs
Non selective
Phenoxybenzamine phentolamine
What are the drugs in selective alpha 1 blocker
Prazosin
Terazosin
Doxazosin
What is the SE of sel. Alpha1 blocker
First dose phenomenon
Orthostatic hypotension
-syncope
Remedy for selctive alpha 1 blocker
Give first dose at night
Give only 1/2 dose or 1/4 dose for the first dose
Types of beta blocker
Nonselective
Selective
Drugs in nonselective beta blocker
Propanolol
Timolol
Pindolol
Nadolol
