Antihypertensives Flashcards
MOA diuretics
1) Decrease BP via decrease in BV, preventing kidney Na+/H2O reabsorption at distal diluting tubule
2) decrease urine calcium excretion
Indication diuretics
1st line HTN, edema
S/E diuretics
hyponatremia, hypokalemia, hypomagnesium, hypercalemia, increase cholesterol, hyperurcemia, hyperglycemia
Caution diuretics
DM, gout
C/I diuretics
sulfa allergy
MOA Loop
Inhibit transport across thick ascending limb of loop of hence–> increased excretion of H2O, Na, Cl, K+ at proximal and distal tubule
Strongest diuretic
loop
Indication loop
HTN, CHF with severe edema, hypercalcemia, mild renal disease
S/E Loop
volume depletion, hypokalemia, hyponatremia, hypocalcemia, hyperuricemia, hypochloremic metabolic alkalosis, hyperglycemia
C/I Loop
Sulfa allergy
MOA potassium sparing diuretic
inhibit aldosterone-mediated Na/H20 absorption–> K+ spared
When best to use potassium sparing diuretic
with loop to save potassium
Indication potassium sparing
Edema Ascites HF HTN Primary aldosteronism PCOS
S/E potassium sparing
hyperkalemia, gynecomastia with spironolactone
C/I potassium sparing
renal failure, hyponatremia