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Flashcards in Antimetabolites Deck (17)
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1
Q

What is the MOA of antimetabolites, what part of the cell cycle do they arrest, and what type of cell is most susceptible to these?

A

Mimic or reduce normal cell comments necessary for DNA, RNA and protein synthesis
S phase
Rapidly dividing

2
Q

3 mechanisms of resistance to antimetabolites?

A

Don’t let these guys metabolize to active forms
Stop transporting
Lower FPGS

3
Q

1 unique adverse effect of antimetabolites?

A

Hand foot syndrome, painful swelling of hands and feet.

4
Q

2 cancers we use methotrexate for?

A

Breast and NHL

5
Q

2 cancers to treat with pemetrexed?

A

Mesothelioma

NSCLC

6
Q

What cancer do we treat with pralatrexate?

A

T cell lymphoma

7
Q

What drug is the most widely used chemo drug against colorectal cancer? What else does this drug work well against as far as cancers?

A

5 fu

Variety of solid tumors

8
Q

What is capecitabine metabolized into, what are two cancers it is used for, and what is the regimen it is part of with what drug to treat what cancer?

A

5FU
Metastatic breast and colorectal
XELOX where it is combined with oxaliplatin as first line treatment for colorectal metastatic cancer

9
Q

What cancer do we use TAS 102 for?

A

Colorectal

10
Q

What cancers do we use cytarabine for and what cancers does it have no activity for?

A

Blood cancers like AML and NHL

No activity against solid tumors

11
Q

What can we use gemcitabine for?

A

Solid and hematologists cancers

12
Q

The thiopurines are metabolized by what enzyme and loss of this enzyme leads to what?

A

TPMT
If we don’t have this those drugs are hanging around causing their adverse effects stronger and longer. Myelosuppression and GI

13
Q

What do we use 6 mercaptopurine for, what cancer?

A

Childhood AL

14
Q

What cancer do we treat with 6 thioguanine?

A

Adult acute leukemia

15
Q

Big time adverse effect of fludrarabine and what do we need to do about it?

A

Potent immunosuppressant. Increased risk of opportunistic infection. Pneumocystis jiroveci pneumonia. Need to give TMP/SMX

16
Q

2 cancers we treat with fludrarabine?

A

NHL and CLL

17
Q

Big time adverse effect of cladribine and what 3 cancers does it treat?

A

Low cd4 and CD8, so immunosuppressant

Hair cell, NHL, CLL