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Flashcards in Antitumor Antibiotics Deck (11)
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1
Q

What are the most widely used anti tumor antibiotics, what is their MOA, and what is a big time toxicity?

A

Anthracyclines
Inhibit topo 2
Cardiotoxicity

2
Q

What is one of the most important chemo drugs in clinical practice, how is it used and what can it treat?

A

Doxorubicin
In conjunction with cyclo, cisplatin and 5FU
Everything

3
Q

What cancer do we use daunorubicin for?

A

AML

4
Q

What does idarubibin treat and what do we need to combine it with?

A

AML with cytarabine

5
Q

What cancer does epirubicin treat?

A

Breast cancer

6
Q

Unique adverse effect of mitoxantrone and what 2 cancers does it treat?

A

Blue fingernails, sclera and urine

Prostate and NHL

7
Q

What is the MOA of dexrazoxane and what cancer is it used for?

A

Iron cheating agent

Used in women with metastatic breast cancer to reduce or prevent cardio toxicity

8
Q

MOA of mitomycin, it is the best available drug in combo with what to treat what kind of tumors, what is a special indication of it?

A

Causes DNA cross linking
Combo it with radiation to treat hypoxic tumors
Intravesical treatment of bladder cancer

9
Q

MOA of bleomycin, what is the big time toxicity, and 2 tumors to remember it treats?

A

Single and double DNA breaker
Pulmonary
NHL and HL

10
Q

3 MOA I am thinking with anti tumor antibiotics?

A

Inhibit topo 2
Form DNA cross linking
Single and double strand breaking

11
Q

3 mechanisms of resistance for anti-tumor antibiotics?

A

Point mutations in topo 2
Efflux pumps
Bleomycin hydroplane enzyme